Research progress of interleukin-33 in acute respiratory distress syndrome

Fu Juan; Xu Fang

doi:10.13406/j.cnki.cyxb.000851

您当前的位置：

首页 >

文章列表页 >

Research progress of interleukin-33 in acute respiratory distress syndrome

更新时间：2024-01-17

- Research progress of interleukin-33 in acute respiratory distress syndrome
- Journal of Chongqing Medical University Vol. 41, Issue 4, Pages: 425-428(2016)
- 作者机构：
  
  重庆医科大学附属第一医院急诊医学科和重症医学科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000851
  CLC： R563.8
- Published：2016，
扫描看全文
[1]付娟,徐昉.白介素-33在急性呼吸窘迫综合征中的研究进展[J].重庆医科大学学报,2016,41(04):425-428.

Fu Juan, Xu Fang. Research progress of interleukin-33 in acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University 41(4):425-428(2016)
[1]付娟,徐昉.白介素-33在急性呼吸窘迫综合征中的研究进展[J].重庆医科大学学报,2016,41(04):425-428. DOI： 10.13406/j.cnki.cyxb.000851.

Fu Juan, Xu Fang. Research progress of interleukin-33 in acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University 41(4):425-428(2016) DOI： 10.13406/j.cnki.cyxb.000851.

摘要

急性呼吸窘迫综合征（acute respiratory distress syndrome

ARDS）是以顽固性低氧血症和进行性呼吸困难为主要临床特点的综合征

是危重症患者死亡的主要原因之一。尽管

近年来医疗技术的迅猛发展和新的药物的应用使ARDS的预后有所改善

但其病死率仍高达40%

0%。因此

更充分的了解ARDS的发病机制

实现早期诊断

为临床上ARDS的防治提供指导仍是呼吸和重症医学界研究的重点和热点。白介素（interleukin

IL）-33是新近发现的IL-1家族成员

在炎症、感染、自身免疫性疾病等多种疾病中发挥重要的警报素作用

促进机体的炎症反应

加重机体组织的损伤。故IL-33及其信号通路可能成为阻断炎症通路的级联反应的一个潜在的分子靶点。本文就IL-33在ARDS中的研究进展做一综述。

Abstract

Acute respiratory distress syndrome(ARDS)is a clinical syndrome characterized by refractory hypoxemia and progressive dyspnea. It is one of the leading causes of death in critically illed patients. In recent years

although the rapid development of medical technology and the application of new drugs have improved the prognosis of ARDS

the mortality of ARDS is still as high as 40%-50%. Therefore

it is still the focus and hotpot in the research of respiratory and intensive medicine to further understand the pathogenesis of ARDS

achieve early diagnosis

and provide guidance for the prevention and treatment of ARDS. Interleukin-33(IL-33)is a recently discovered member of the Interleukin-1(IL-1)family. It plays a crucial role as an alarmins in inflammation

infection

au toimmune disease and many other diseases

enlarges the body’s inflammatory response

and aggravate tissue injury. Therefore

IL-33 and its signal pathway probably become potential molecular targets to block the cascade of inflammatory pathways in the treatment of ARDS. In this paper

we reviewed on the role of IL-33 in ARDS.

关键词

急性呼吸窘迫综合症白介素-33细胞因子警报素信号通路

Keywords

acute respiratory distress syndromeinterleukin-33cytokinesalarminssignal pathway

references

Views

171

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress of high mobility group box-1 in acute lung injury/acute respiratory distress syndrome

A review of new progress in PIK3CA-related overgrowth spectrum research

Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2

Relationship between expression of autophagy regulation interleukin-33 and the pathogenesis of preeclampsia

Study on the antitumor immune effect induced by dendritic cells derived from chronic myeloid leukemia

Related Author

Gao Feng

Xu Fang

Zhu Jing

Leng Jie

Wu Ying

Cheng Xinran

Zhang Jing

Lin Lan

Related Institution

Department of Emergency and Intensive Care Unit，The First Affiliated Hospital of Chongqing Medical University

The Children's Hospital Chongqing Medical University，Ministry of Education Key Laboratory of Developmental Disease in Childhood

Department of Children's Endocrine and Genetic Metabolism，Chengdu Women's and Children's Central Hospital，School of Medicine，University of Electronic Science and Technology of China

Department of Dermatology,Chongqing Zhongshan Hospital

Department of Dermatology,Chongqing Emergency Medical Center

⁰