Changes of rats ovarian granular cells under high-fat fed state

Li Cong; Wang Lianlian; Hu Xiaojing

doi:10.13406/j.cnki.cyxb.000850

您当前的位置：

首页 >

文章列表页 >

Changes of rats ovarian granular cells under high-fat fed state

更新时间：2024-01-17

- Changes of rats ovarian granular cells under high-fat fed state
- Journal of Chongqing Medical University Vol. 41, Issue 2, Pages: 172-175(2016)
- 作者机构：
  
  重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000850
  CLC： R589.2;R711.75
- Published：2016，
扫描看全文
[1]李聪,王炼炼,胡小靖.高脂喂养下大鼠卵巢颗粒细胞的功能变化[J].重庆医科大学学报,2016,41(02):172-175.

Li Cong, Wang Lianlian, Hu Xiaojing. Changes of rats ovarian granular cells under high-fat fed state. [J]. Journal of Chongqing Medical University 41(2):172-175(2016)
[1]李聪,王炼炼,胡小靖.高脂喂养下大鼠卵巢颗粒细胞的功能变化[J].重庆医科大学学报,2016,41(02):172-175. DOI： 10.13406/j.cnki.cyxb.000850.

Li Cong, Wang Lianlian, Hu Xiaojing. Changes of rats ovarian granular cells under high-fat fed state. [J]. Journal of Chongqing Medical University 41(2):172-175(2016) DOI： 10.13406/j.cnki.cyxb.000850.

摘要

目的:分析高脂血症与卵巢颗粒细胞的影响

了解对卵巢激素合成功能的改变。方法:高脂喂养大鼠至性成熟期

测定卵巢组织内颗粒细胞的形态改变

免疫组化和Western blot测定性激素受体和生长分化因子9（growth differentiation factor-9

GDF-9）的蛋白水平改变。结果:高脂喂养后

颗粒细胞的出现病理性改变

其雌孕雄激素受体含量减少

GDF-9在卵巢组织内表达减弱

说明高脂喂养后卵巢颗粒细胞功能的减弱。结论:高脂喂养后

颗粒细胞结构出现损伤性改变

激素合成功能下降

与高脂血症下排卵减弱的临床症状相符合

提示高脂血症影响卵巢排卵功能的不良作用可通过损伤颗粒细胞来实现。

Abstract

Objective:To understand the function of ovarian hormone synthesis change through the analysis of the change of hyperlipidemia and granulosa cells. Methods:Rats under high-fat were fed to sexual mature. Ovarian granulosa cells were observed by transmission electron microscope

and sex hormone receptors and growth differentiation factor-9(GDF-9)changes in ovarian granulosa cells were detected by immunohistochemistry and Western blot. Results:After high-fat diet

granule cell pathological changes being found;estrogen

progesterone and androgen receptors levels were reduced obviously;the expression of GDF-9 in ovarian tissues was weakened;ovarian cell function was declined. Conclusion:After high-fat fed

the damage change of granular cell structure and the decline of hormone synthesis function are consistent with the clinical symptoms of weakened ovulation under hyperlipemia

suggesting the role of hyperlipidemia for weaken ovarian ovulation function by injuring granular cell.

关键词

高脂血症颗粒细胞生长分化因子-9

Keywords

hyperlipidemiaGranulosa cellsgrowth differentiation factor-9

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preliminary study on the potential molecular net work interaction of ferroptosis in liver transcriptome of ApoE^-/-hyperlipidemic mice

Relationship between serum uric acid level and hyperlipidemia

Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia

Effect of polycystic ovary-like environment on E₂ and P levels in human granulosa cells in vitro

Experimental study on lipid regulation function of the Xi-zhi-jiang Capsule

Related Author

Wenna Chen

Xin Zhang

陈运贞

雷寒

马康华

et al

LIU Jian

陈运贞

Related Institution

Teaching and Research Center, Liaoning University of Traditional Chinese Medicine

Postgraduate School, Liaoning University of Traditional Chinese Medicine

重庆医科大学临床学院心内科

Cardiology Division,College of Clinical Medicine,Chongqing Medical University

Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

⁰