Effect of parthenolide on intimal hyperplasia after balloon injury and the underlying mechanism

Mao Xia; Gao Lihua; Deng Changming

doi:10.13406/j.cnki.cyxb.000844

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Effect of parthenolide on intimal hyperplasia after balloon injury and the underlying mechanism

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- Effect of parthenolide on intimal hyperplasia after balloon injury and the underlying mechanism
- Journal of Chongqing Medical University Vol. 41, Issue 2, Pages: 191-195(2016)
- 作者机构：
  
  重庆医科大学附属第二医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000844
  CLC： R541.4
- Published：2016，
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[1]毛霞,高丽华,邓昌明.小白菊内酯对球囊损伤后内膜增殖的影响及其机制[J].重庆医科大学学报,2016,41(02):191-195.

Mao Xia, Gao Lihua, Deng Changming. Effect of parthenolide on intimal hyperplasia after balloon injury and the underlying mechanism. [J]. Journal of Chongqing Medical University 41(2):191-195(2016)
[1]毛霞,高丽华,邓昌明.小白菊内酯对球囊损伤后内膜增殖的影响及其机制[J].重庆医科大学学报,2016,41(02):191-195. DOI： 10.13406/j.cnki.cyxb.000844.

Mao Xia, Gao Lihua, Deng Changming. Effect of parthenolide on intimal hyperplasia after balloon injury and the underlying mechanism. [J]. Journal of Chongqing Medical University 41(2):191-195(2016) DOI： 10.13406/j.cnki.cyxb.000844.

摘要

目的:探讨小白菊内酯（parthenolide

PN）对球囊损伤后内膜增殖的影响及其可能机制。方法:通过球囊损伤联合高脂喂养建立兔髂血管炎症反应及内膜增殖模型

将30只兔高脂适应性喂养1周后随机分为6组:对照组:假手术+0.9%生理盐水（normal saline

NS）（n=5）;假手术+4%二甲基亚砜（dimethyl sulfoxide

DMSO）（n=5）;模型组:球囊损伤+0.9%NS（n=5）;球囊损伤+4%DMSO（n=5）;治疗组（PN溶解于4%DMSO）:低剂量:球囊损伤+PN 1 mg/（kg·d）（n=5）;高剂量:球囊损伤+PN 2 mg/（kg·d）（n=5）

假手术组分离结扎股动脉不行球囊损伤

术后立即按分组给药。4周后检测比较各组血管内膜增殖、核转录因子-κB（nuclear transcription factor-κB

NF-κB）、白介素（interleukin

IL）-6和肿瘤坏死因子（tumor necrosis factor

TNF）-α的表达。结果:模型组与对照组比较

内膜厚度、NF-κB、IL-6和TNF-α明显增加（P<0.05）;治疗组与模型组比较

上述指标在高剂量组显著降低（P<0.05）。结论:PN通过抑制NF-κB及其下游炎症因子IL-6和TNF-α表达来抑制炎症反应

从而抑制内膜增殖。

Abstract

Objective:To detect the effect of parthenolide(PN)on intimal hyperplasia and the underlying mechanism. Methods:The inflammatory model of intimal hyperplasia was established by a combination of balloon injury and high-fat diet. After one week of high-fat feeding

30 rabbits were randomly divided into 6 groups. Control groups:rabbits got 0.9% normal saline(NS

n=5)or 4% DMSO(n=5)after sham operation. Model groups:rabbits got equal volume of 0.9% NS(n=5)or 4% DMSO(n=5)after balloon injury. PN groups(PN dissolved in 4% DMSO):rabbits immediately injected with PN(dissolved in 4%DMSO)at 1 mg/(kg·d)(low)or2 mg/(kg·d)(high) after balloon injury. Four weeks later

the thicknesses of intima

the expression of nuclear transcription factor-κB(NF-κB)

interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α)were detected. Results:Compared with those of control groups

the thickness of intima

the amount of NF-κB

IL-6and TNF-α in model groups were significantly increased(P<0.05);compared with those of high dose group

the thickness of intima

the amount of NF-κB

IL-6 and TNF-α in model groups were significantly decreased(P<0.05). Conclusion:PN suppresses intimal hyperplasia by inhibiting the expressions of NF-κB

IL-6 and TNF-α.

关键词

小白菊内酯球囊损伤内膜增殖核转录因子-κB

Keywords

parthenolideballoon injuryintimal hyperplasianuclear factor-κB

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