Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer’s disease

Wang Fang; Wu Rui; Liu Heyu

doi:10.13406/j.cnki.cyxb.000842

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Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer’s disease

更新时间：2024-01-17

- Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer’s disease
- Journal of Chongqing Medical University Vol. 41, Issue 1, Pages: 73-75(2016)
- 作者机构：
  
  1. 郑州大学第二附属医院
  2. 郑州大学第二附属医院神经康复科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000842
  CLC： R749.16
- Published：2016，
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[1]王芳,吴睿,刘合玉.随访间血压变异性对阿尔茨海默病患者认知功能变化的影响[J].重庆医科大学学报,2016,41(01):73-75.

Wang Fang, Wu Rui, Liu Heyu. Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer’s disease. [J]. Journal of Chongqing Medical University 41(1):73-75(2016)
[1]王芳,吴睿,刘合玉.随访间血压变异性对阿尔茨海默病患者认知功能变化的影响[J].重庆医科大学学报,2016,41(01):73-75. DOI： 10.13406/j.cnki.cyxb.000842.

Wang Fang, Wu Rui, Liu Heyu. Effect of visit-to-visit blood pressure variability on the cognitive decline in patients with Alzheimer’s disease. [J]. Journal of Chongqing Medical University 41(1):73-75(2016) DOI： 10.13406/j.cnki.cyxb.000842.

摘要

目的:观察随访间血压波动对阿尔茨海默病（Alzheimer disease

AD）患者认知功能降低变化的影响

探讨血压波动与认知功能降低之间的关系。方法:选取111位轻中度AD患者完成为期1年的随访。用简明精神状态量表（mini-mental state examination

MMSE）评估认知功能

详细记录其血压波动情况。用关联性分析和多元逐步回归分析探索两者之间的关系。结果 :多元逐步回归分析显示仅动脉血压波动可以解释MMSE评分的降低。结论:随访间血压变异性是评估AD患者认知功能恶化进程的一个重要指标。

Abstract

Objective:To investigate whether visit-to-visit blood pressure variability influences the rate of cognitive decline in Alzheimer disease(AD)patients. Methods:A total of 111 patients with mild to moderate AD have completed this evaluation. Assessment of cognitive function was conducted using mini-mental state examination(MMSE) and the variation of blood pressure was recorded. Correlating analyses and multiple stepwise regression analysis were used to do statistical analysis. Results:Multiple stepwise regression analysis showed that only arterial blood pressure variability can explain the decrease in MMSE score. Conclusion:Follow-up blood pressure variability is an important evaluation index of cognitive function deterioration process.

关键词

简明精神状态量表阿尔茨海默病随访间血压波动认知功能

Keywords

mini-mental state examinationAlzheimer’s diseasefollow-up blood pressure variabilitycognitive function

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