Inflammation and immunosuppression after traumatic brain injury

Zhang Weidan; Zhao Jing; Zhai Xuan

doi:10.13406/j.cnki.cyxb.000833

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Inflammation and immunosuppression after traumatic brain injury

更新时间：2024-01-17

- Inflammation and immunosuppression after traumatic brain injury
- Journal of Chongqing Medical University Vol. 41, Issue 1, Pages: 1-4(2016)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院神经外科
  2. 重庆医科大学基础医学院病理生理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000833
  CLC： R651.15
- Published：2016，
扫描看全文
[1]张为丹,赵敬,翟瑄.脑创伤后炎症反应与免疫抑制[J].重庆医科大学学报,2016,41(01):1-4.

Zhang Weidan, Zhao Jing, Zhai Xuan. Inflammation and immunosuppression after traumatic brain injury. [J]. Journal of Chongqing Medical University 41(1):1-4(2016)
[1]张为丹,赵敬,翟瑄.脑创伤后炎症反应与免疫抑制[J].重庆医科大学学报,2016,41(01):1-4. DOI： 10.13406/j.cnki.cyxb.000833.

Zhang Weidan, Zhao Jing, Zhai Xuan. Inflammation and immunosuppression after traumatic brain injury. [J]. Journal of Chongqing Medical University 41(1):1-4(2016) DOI： 10.13406/j.cnki.cyxb.000833.

摘要

脑创伤（traumatic brain injury

TBI）后血脑屏障（blood brain barrier

BBB）受损

脑内固有免疫细胞（小胶质细胞、星型胶质细胞等）和外周来源免疫细胞（巨噬/单核细胞、T细胞、中性粒细胞等）均参与到脑组织的炎症反应中

释放多种炎症因子、活性氧、化学诱导物

造成脑组织损伤

同时引发机体对免疫细胞的产生和功能的抑制性调节

即免疫抑制。本文就TBI后脑内炎症反应和外周免疫抑制方面的研究作一综述

旨在进一步了解其病理生理改变

为临床治疗提供理论依据。

Abstract

The blood brain barrier(BBB)are damaged after traumatic brain injury(TBI). Resident immune cells including microglia

astrocytes and periphery immune cells(monocytes/macrophages

T-cells

neutrophils

etc)are involved in the inflammation reaction of brain tissue. These cells release a variety of inflammatory factor

reactive oxygen species

chemical inducer

result in brain damage

and pull the trigger of the inhibitive regulation to depress the manufacture and feature of immune cells at the same time(immunosuppression). This review describes the mechanism of brain inflammation and peripheral immunosuppression after TBI through the acquaintance of the pathophysiologic proceeding to provide advices and basis for clinical therapy.

关键词

脑创伤炎症反应免疫抑制

Keywords

traumatic brain injuryinflammation responseimmunosuppression

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Department of Nephrology,The First Affiliated Hospital of Chongqing Medical University

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