Research progress in the melanomas after nanosecond pulsed electric fields treatment

Pang Yunqing; Zhang Li; Wang Jing

doi:10.13406/j.cnki.cyxb.000832

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Research progress in the melanomas after nanosecond pulsed electric fields treatment

更新时间：2024-01-17

- Research progress in the melanomas after nanosecond pulsed electric fields treatment
- Journal of Chongqing Medical University Vol. 41, Issue 5, Pages: 537-540(2016)
- 作者机构：
  
  兰州大学口腔医学院口腔内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000832
  CLC： R739.5
- Published：2016，
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[1]庞云清,张莉,王静.纳秒脉冲电场治疗黑色素瘤的机制[J].重庆医科大学学报,2016,41(05):537-540.

Pang Yunqing, Zhang Li, Wang Jing. Research progress in the melanomas after nanosecond pulsed electric fields treatment. [J]. Journal of Chongqing Medical University 41(5):537-540(2016)
[1]庞云清,张莉,王静.纳秒脉冲电场治疗黑色素瘤的机制[J].重庆医科大学学报,2016,41(05):537-540. DOI： 10.13406/j.cnki.cyxb.000832.

Pang Yunqing, Zhang Li, Wang Jing. Research progress in the melanomas after nanosecond pulsed electric fields treatment. [J]. Journal of Chongqing Medical University 41(5):537-540(2016) DOI： 10.13406/j.cnki.cyxb.000832.

摘要

恶性黑色素瘤是最具侵袭性的皮肤癌

发病率高且临床治疗困难。研究表明纳秒脉冲电场（nanosecond pulsed electric fields

ns PEFs）可通过抑制肿瘤血供和诱导凋亡而抑制黑色素瘤的生长

并且ns PEFs能抑制黑色素瘤的转移并能激活机体对肿瘤的免疫反应。相比传统的手术治疗

ns PEFs具有高度局限、非热能、几乎无瘢痕和无副作用等优势。近年来对ns PEFs治疗黑色素瘤的研究逐渐增多

本文对近年来ns PEFs治疗黑色素瘤的有效性、安全性和治疗机制等研究概况进行综述

以期为后续的实验研究和临床应用提供依据。

Abstract

Malignant melanoma is the most aggressive form of skin cancer and it is difficult to treat. The incidence of melanoma has been continuously increasing. Studies have shown that melanoma growth was inhibited by nanosecond pulsed electric fields(ns PEFs)treatment by inducing apoptosis and suppressing angiogenesis. Furthermore

ns PEFs treatment can stimulate immune response and inhibit tumor metastasis. The advantages of ns PEFs therapy are non-thermal

high-limited

almost no scarring and even no side effect. In recent years

the studies about ns PEFs treatment of melanoma are increasing. Therefore

in order to provide more evidence for subsequent research and clinical application

the efficiency

safety and treatment mechanism of ns PEFs therapy are reviewed here.

关键词

ns PEFs黑色素瘤凋亡免疫反应转移

Keywords

ns PEFsmelanomaapoptosisimmune responsemetastasis

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Related Institution

Department of Cell Biology and Genetics

Molecular Medicine and Tumor Research Center，Chongqing Medical University

Department of Gastrointestinal Surgery，The Third Affiliated Hospital of Zunyi Medical University/ The First People’s Hospital of Zunyi

Department of Critical Care Medicine,General Hospital of Ningxia Medical University

Department of Respiratory Medicine,Cangzhou People's Hospital

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