Effects of GLP-1 receptor agonist on Zinc-α2-glycoprotein and its relationship with insulin resistance in patients with newly diagnosed type 2 diabetes

Tan Xingrong; Liang Zerong; Li Shengbing; Tang Shiguo; Fang Chao; Tang Lihua; Pi Yan; Qin Fen; Wang Yi

doi:10.13406/j.cnki.cyxb.000817

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Effects of GLP-1 receptor agonist on Zinc-α2-glycoprotein and its relationship with insulin resistance in patients with newly diagnosed type 2 diabetes

更新时间：2024-01-17

- Effects of GLP-1 receptor agonist on Zinc-α2-glycoprotein and its relationship with insulin resistance in patients with newly diagnosed type 2 diabetes
- Journal of Chongqing Medical University Vol. 40, Issue 11, Pages: 1395-1400(2015)
- 作者机构：
  
  1. 重庆市第九人民医院内分泌科
  2. 重庆市红十字医院-江北区医院内分泌科
  3. 重庆医科大学附属第二医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000817
  CLC： R587.1
- Published：2015，
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[1]谭兴容,梁泽容,李生兵,汤世国,方超,汤利华,皮艳,秦芬,王毅.GLP-1受体激动剂对锌-α2-糖蛋白的影响及其与胰岛素抵抗关系[J].重庆医科大学学报,2015,40(11):1395-1400.

Tan Xingrong, Liang Zerong, Li Shengbing, et al. Effects of GLP-1 receptor agonist on Zinc-α2-glycoprotein and its relationship with insulin resistance in patients with newly diagnosed type 2 diabetes. [J]. Journal of Chongqing Medical University 40(11):1395-1400(2015)
[1]谭兴容,梁泽容,李生兵,汤世国,方超,汤利华,皮艳,秦芬,王毅.GLP-1受体激动剂对锌-α2-糖蛋白的影响及其与胰岛素抵抗关系[J].重庆医科大学学报,2015,40(11):1395-1400. DOI： 10.13406/j.cnki.cyxb.000817.

Tan Xingrong, Liang Zerong, Li Shengbing, et al. Effects of GLP-1 receptor agonist on Zinc-α2-glycoprotein and its relationship with insulin resistance in patients with newly diagnosed type 2 diabetes. [J]. Journal of Chongqing Medical University 40(11):1395-1400(2015) DOI： 10.13406/j.cnki.cyxb.000817.

摘要

目的:阐明锌-α2-糖蛋白（Zinc-α2-glycoprotein

ZAG）与胰岛素抵抗的关系以及胰升糖素样肽1（glucagon-like peptide-1

GLP-1）受体激动剂治疗的影响。方法:新发2型糖尿病（newly diagnosed T2DM

n T2DM）患者120例随机分为利拉鲁肽组（n=45

利拉鲁肽0.6

.8 mg

i H qd）、利拉鲁肽+二甲双胍组（n=45

利拉鲁肽0.6

.8 mg

i H qd+二甲双胍0.5g bid）、安慰剂组（n=30

生理盐水150μl i H qd+二甲双胍0.5g bid）

治疗12周

同期选取年龄、性别相匹配的健康体检者作为健康对照组（n=30）。治疗前后分别行75g OGTT、胰岛素钳夹试验并检测血浆ZAG、脂联素（adiponectin

ADI）水平及相关代谢指标。结果:n T2DM患者基础血浆ZAG水平明显低于健康对照组（P

0.01）

通过利拉鲁肽、利拉鲁肽+二甲双胍治疗后12周

患者的糖化血红蛋白

空腹血糖

糖负荷后2 h血糖

甘油三酯和稳态模型评估胰岛素抵抗指数均较治疗前明显下降（P

0.05）

通过安慰剂治疗后上述指标明显高于利拉鲁肽治疗组（P

0.05）;而在钳夹过程中

M值明显升高（P

0.01）。此外

与治疗前相比

利拉鲁肽治疗后血浆ZAG、ADI水平明显增加（P

0.01）。结论:n T2DM患者经GLP-1受体激动剂治疗后

糖代谢及胰岛素敏感性得到明显改善

血浆ZAG水平也明显升高

提示ZAG将可能被作为代谢综合征或者T2DM的一个新的生物标志物。

Abstract

Objective:To illuminate the relation of Zinc-α2-glycoprotein(ZAG)and insulin resistance(IR)in patients with newly diagnosed type 2 diabetes(n T2DM)

and to examine the effect of glucagon-like peptide-1(GLP-1) receptor agonist on ZAG and adiponectin(ADI). Methods:Totally 120 subjects with n T2 DM were assigned randomly to receive placebo(normal saline+metformin)or liraglutide

or metformin + liraglutide for 12 weeks. Before and after the treatment

subjects received 75 g OGTT

euglycemic-hyperinsulinemic clamp(EHCs)

and measurement of metabolic index

serum ZAG and ADI concentrations. Results:Circulating ZAG was significantly lower in n T2 DM than in normal individuals(P<0.01). After 12 weeks of liraglutide or metformin + liraglutide

glycosylated hemoglobin(Hb A1c)

fasting blood glucose(FBG)

oral glucose tolerance test 2 hour blood glucose(2h BG)

triglycerides(TG)and HOMA-IR were decreased significantly compared with those of pre- treatment(P < 0. 05)

whereas M values during EHCs were significantly increased(P <0.01). Importantly

after the treatment with liraglutide

circulating ZAG and ADI concentrations were significantly increased along with improved glucose metabolism and insulin sensitivity compared with those of pre-treatment(both P<0.01). Conclusion:Circulating ZAG level

insulin resistance and glucolipid metabolism are significantly increased after with liraglutide treatment. ZAG can be used as a novel biomarker for metabolic syndrome and T2 DM.

关键词

锌-α2-糖蛋白脂联素GLP-1受体激动剂2型糖尿病

Keywords

Zinc-α2-glycoproteinadiponectinglucagon-like peptide-1 receptor agonisttype 2 diabetes mellitus

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