Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy

Hu Yumei; Xia Jiajia; Ren Wei

doi:10.13406/j.cnki.cyxb.000813

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Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy

更新时间：2024-01-17

- Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy
- Journal of Chongqing Medical University Vol. 40, Issue 11, Pages: 1387-1389(2015)
- 作者机构：
  
  重庆医科大学附属第一医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000813
  CLC： R587.1
- Published：2015，
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[1]胡钰梅,夏佳佳,任伟.钠-葡萄糖共转运蛋白2抑制剂对糖尿病肾病的保护作用[J].重庆医科大学学报,2015,40(11):1387-1389.

Hu Yumei, Xia Jiajia, Ren Wei. Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy. [J]. Journal of Chongqing Medical University 40(11):1387-1389(2015)
[1]胡钰梅,夏佳佳,任伟.钠-葡萄糖共转运蛋白2抑制剂对糖尿病肾病的保护作用[J].重庆医科大学学报,2015,40(11):1387-1389. DOI： 10.13406/j.cnki.cyxb.000813.

Hu Yumei, Xia Jiajia, Ren Wei. Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy. [J]. Journal of Chongqing Medical University 40(11):1387-1389(2015) DOI： 10.13406/j.cnki.cyxb.000813.

摘要

钠-葡萄糖共转运蛋白2（sodium-glucose cotransporters-2

SGLT2）抑制剂是一种新型的降糖药物。目前有研究表明SGLT2抑制剂除有效降低血糖外

对糖尿病肾病可能有保护作用

主要表现在减少尿蛋白、降低血尿酸、改善肾脏组织学及形态学的病理学改变等

可能与抗氧化、抗炎、抗纤维化

改善肾脏的高滤过

降血压等机制有关。

Abstract

Sodium-glucose cotransporter-2(SGLT2)inhibitors have been developed as a novel antihyperglycaemic agent. The current studies have shown that SGLT2 inhibitors can effectively lower blood glucose. In addition

SGLT2 inhibitor may play a role in the protection of the diabetic nephropathy

mainly to reduce urinary protein

lower blood uric acid

improve renal histological and morphological pathology

etc. The mechanism may be associated with its anti-oxidant

anti-inflammatory

anti-fibrotic effects

renal hyperfiltration improvement

blood pressure reduce

etc.

关键词

钠-葡萄糖共转运蛋白2抑制剂糖尿病糖尿病肾病

Keywords

sodium glucose cotransporter 2 inhibitorsdiabetes mellitusdiabetic nephropathy

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Related Institution

Department of Endocrinology，The First Affiliated Hospital of Chongqing Medical University

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河北省中医院导管室

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Department of Traditional Chinese Medicine,Xinqiao Hospital,Third Military Medical University

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