Coffee consumption and risk of gallstone disease:a systematic review

Chen Lanfang; Hu Zhen; Chen Wensheng

doi:10.13406/j.cnki.cyxb.000811

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Coffee consumption and risk of gallstone disease:a systematic review

更新时间：2024-01-17

- Coffee consumption and risk of gallstone disease:a systematic review
- Journal of Chongqing Medical University Vol. 41, Issue 3, Pages: 298-306(2016)
- 作者机构：
  
  第三军医大学西南医院全军消化病研究所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000811
  CLC： R575.62
- Published：2016，
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[1]陈兰芳,胡珍,陈文生.咖啡与胆囊结石发生风险的系统评价[J].重庆医科大学学报,2016,41(03):298-306.

Chen Lanfang, Hu Zhen, Chen Wensheng. Coffee consumption and risk of gallstone disease:a systematic review. [J]. Journal of Chongqing Medical University 41(3):298-306(2016)
[1]陈兰芳,胡珍,陈文生.咖啡与胆囊结石发生风险的系统评价[J].重庆医科大学学报,2016,41(03):298-306. DOI： 10.13406/j.cnki.cyxb.000811.

Chen Lanfang, Hu Zhen, Chen Wensheng. Coffee consumption and risk of gallstone disease:a systematic review. [J]. Journal of Chongqing Medical University 41(3):298-306(2016) DOI： 10.13406/j.cnki.cyxb.000811.

摘要

目的:探讨饮用咖啡与胆囊结石发生风险的关系。方法:计算机检索数据库Pub Med（1809年至2015年2月1日）、EMBASE（1966年至2015年2月2日）、Web of Science（1950年至2015年2月3日）、Cochrane Library（1950年至2015年2月4日）、中国生物医学文献数据库（1978年至2015年2月5日）、中国期刊全文数据库（1979年至2015年2月6日）、万方（1950年至2015年2月7日）、维普（1989年至2015年2月8日）

收集关于饮用咖啡与胆囊结石发生风险关系的观察性研究。两名研究员按纳入与排除标准独立筛选文献、提取资料后

应用STATA 11.0软件进行统计分析（固定效应模型Mantel-Haenszel（M-H）法

随机效应模型Dersimonian-Laird（D-L）法

异质性检验应用Q统计量和I2统计量检验

发表偏倚应用Begg’s和Egger’s检验）。结果:共纳入文献14篇

其中队列研究5篇

累积样本量226 432人;回顾性研究9篇

累积样本量29 111人。队列研究Meta-分析结果显示

饮用咖啡可降低胆囊结石发生的风险（RR=0.76

95%CI=0.71

.81

P=0.000）

回顾性研究Meta分析结果显示

还不能认为饮用咖啡与胆囊结石之间有统计学差异（OR=0.88

95%CI=0.67

.16

P=0.366）。亚组分析结果显示

饮用含咖啡因的咖啡胆囊结石发生风险降低（OR=0.76

95%CI=0.71

.81

P=0.000）

饮用量为2

杯/d和

3杯/d时胆囊结石的发生风险降低（OR=0.84

95%CI=0.80

.88

P=0.000）（OR=0.81

95%CI=0.69

.96

P=0.014）

饮用咖啡女性胆囊结石发生风险降低（OR=0.77

95%CI=0.72

.83

P=0.000）。结论:饮用咖啡可能降低胆囊结石发生的风险

这种作用主要表现在含咖啡因咖啡。当咖啡饮用量超过2杯/d时

对胆囊结石有预防效果

另外咖啡对预防女性胆囊结石的发病作用明显。

Abstract

Objective:To evaluate the relationship between coffee consumption and risk of gallstone disease. Methods:The database of Pub Med(1809-2015.02.01)

EMBASE(1966-2015.02.02)

Web of Science(1950-2015.02.03)

Cochrane Library(1950-2015.02.04)

CBM(1978-2015.02.05)

CNKI(1979-2015.02.06)

WANFANG(1950-2015.02.07)

VIP(1989-2015.02.08)were searched with relevant terms. Observational studies of coffee consumption and risk of gallstone disease were collected. Two reviewers independently screened and selected articles based on predetermined inclusion and exclusion criteria. After data being extracted

STATA 11.0 software was used for statistical analysis(Fixed-effects mode with method of Mantel-Haenszel(M-H)

random-effects mode with method of Dersimonian-Laird(D-L). Statistical heterogeneity was evaluated through the Q test and I2 statistic. Egger’s test and Begg’s method was used to assess publish bias). Results:Fourteen studies

including five cohort studies with 226 432 participants and nine retrospective studies with 29 111 participants

who met the inclusion criteria were analyzed. Pooled result of prospective studies showed that coffee consumption was associated with reduction of gallstone disease(RR=0.76

95%CI=0.71 to 0.81

P=0.000). Pooled result of retrospective studies showed no statistical significance between coffee consumption and gallstone risk(OR=0.88

95%CI=0.67 to 1.16

P=0.366). Subgroup analysis showed that consumption of caffeinated coffee was associated with reduction of gallstone disease(OR=0.76

95%CI=0.71 to 0.81

P=0.000);coffee drinking 2-3 cups/day or >3 cups/day was associated with reduction of gallstone disease(OR=0.84

95%CI=0.80 to 0.88

P=0.000)(OR=0.81

95%CI=0.69 to 0.96

P=0.014). Gallstone disease for women was reduced with coffee drinking(OR=0.77

95%CI=0.72 to 0.83

P=0.000). Conclusion:Coffee consumption may reduce risk of gallstone disease;it is more obvious for caffeinated coffee

and this effect is worked if one consuming it more than 2 cups/day. In addition it’s more useful to prevent women from gallstone disease.

关键词

胆囊结石咖啡系统评价Meta分析

Keywords

gallstone diseasecoffeesystematic reviewMeta analysis

references

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