Objective:To discuss whether endometrial polyps and endometrial polyp resection affect the pregnancy rate of infertility patients by conducting systematic review

to guide the routine hysteroscopy during the treatment of infertility patients

which may discover endometrial lesions timely and increase the pregnancy rate obviously. Methods:The Cochrane Central Register of Controller Trails(CENTRAL)

EMBASE

and Pub Med were searched from the date of their inception to 31 January 2015. Observational studies about endometrial polyps and endometrial polypectomy impact on infertility pregnancy were checked. The meta-analysis outcome was analyzed by software Revman 5.3. Risk ratio(RR)with 95% confidence interval(CI)was calculated. Results:Six studies presenting seven results were included. Three studies with a total of 6 094 participants were about whether endometrial polyp in patients with infertility exerts effect on pregnancy rate. There were 454 endometrial polyp cases

among which 112 cases were conceived and the pregnancy rate was 24.47%(112/454). A total of 5 595 cases had no endometrial polyp

among which 1 706 cases were conceived

and the pregnancy rate was 30.49%(1 706/5 595). The outcome showed that endometrial polyp was associated with increased risk of pregnancy rate in patients with infertility(RR =1.19

95% CI=1.01 to 1.40

P=0.030)and there was no heterogeneity among the studies(P=0.410

I2=0%). Four studies on whether polypectomy affect pregnancy rate in infertility were enrolled. There were 222 cases in the treatment group

among which 114 cases were conceived and the pregnancy rate was 51.35%(114/222). There were 227 cases in the control group

among which 60 cases were conceived and the pregnancy rate was 26.43%(60/227). The outcome showed that polypectomy was associated with increased risk of pregnancy rate in infertility patients(RR=1.61

95%CI=1.01 to 2.57

P=0.050)

with moderate heterogeneity among the studies(P=0.030

I2=65%). Conclusion:Endometrial polyp is one of important factors leading to infertility. Infertility patients whose outcome of ultrasound and/or hysterosalpingography is abnormal need to do routine hysteroscopy

in order to exclude endometrial polyp. Once endometrial polyp is diagnosed

surgical treatment should be intervened to improve the pregnancy rate.