Chronic obstructive pulmonary diseases and risk of lung cancer among nonsmokers:a systematic review

Shen Dan; Jiang Depeng; Jiang Youfan

doi:10.13406/j.cnki.cyxb.000800

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Chronic obstructive pulmonary diseases and risk of lung cancer among nonsmokers:a systematic review

更新时间：2024-01-17

- Chronic obstructive pulmonary diseases and risk of lung cancer among nonsmokers:a systematic review
- Journal of Chongqing Medical University Vol. 41, Issue 4, Pages: 360-363(2016)
- 作者机构：
  
  重庆医科大学第二附属医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000800
  CLC： R734.2
- Published：2016，
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[1]沈丹,江德鹏,蒋幼凡.未吸烟人群慢性阻塞性肺疾病与肺癌危险关系的系统评价[J].重庆医科大学学报,2016,41(04):360-363.

Shen Dan, Jiang Depeng, Jiang Youfan. Chronic obstructive pulmonary diseases and risk of lung cancer among nonsmokers:a systematic review. [J]. Journal of Chongqing Medical University 41(4):360-363(2016)
[1]沈丹,江德鹏,蒋幼凡.未吸烟人群慢性阻塞性肺疾病与肺癌危险关系的系统评价[J].重庆医科大学学报,2016,41(04):360-363. DOI： 10.13406/j.cnki.cyxb.000800.

Shen Dan, Jiang Depeng, Jiang Youfan. Chronic obstructive pulmonary diseases and risk of lung cancer among nonsmokers:a systematic review. [J]. Journal of Chongqing Medical University 41(4):360-363(2016) DOI： 10.13406/j.cnki.cyxb.000800.

摘要

目的:探讨未吸烟人群慢性阻塞性肺疾病与肺癌之间的相互关系

为预防决策提供依据。方法:计算机检索Pub Med、中文科技期刊数据库（VIP）、中国期刊全文数据库（CNKI）、万方数字化期刊全文数据库

筛选研究未吸烟人群慢性阻塞性肺疾病与肺癌之间关系的文献

对纳入的文献进行质量评价

采用Review Manager 5.3软件进行Meta分析。结果:共纳入9篇文献

包括肺癌组2 089例

对照组4 519例。Meta分析结果提示

未吸烟人群慢性阻塞性肺疾病与肺癌关系明显

合并OR值为1.46（95%CI=1.26

.70）。这种联系在白种人明显（OR=1.58;95%CI=1.20

.08）

亚洲人中无统计学意义（OR=1.25;95%CI=0.98

.59）。慢阻肺、慢性支气管炎、肺气肿合并OR值分别为1.46（95%CI=1.04

.03）、1.64（95%CI=1.15

.36）和1.47（95%CI=1.17

.83）。结论:慢性阻塞性肺疾病与肺癌可能密切相关。

Abstract

Objective:To provide evidence for decision-making on lung cancer prevention through studying the risk between chronic obstructive pulmonary diseases(COPD) and lung cancer among nonsmokers. Methods :A literature search was conducted in Pub Med

VIP

CNKI and Wang Fang to select the relevant publications on the association between chronic obstructive pulmonary diseases and lung cancer among nonsmokers. Quality of enrolled literatures was assessed and software of Review Manager 5.3 was employed to conduct Meta analysis. Results:Nine studies(2 089 cases and 4 519 controls)were identified. The morbidity rate of chronic obstructive pulmonary diseases was significantly different between lung cancer patients and controls

the pooled odd ratio was1.46(95%CI=1.26 to 1.70). The difference was obvious in White population(OR=1.58;95%CI=1.20 to 2.08)

but there was no statistical difference in Asian population(OR=1.25;95%CI=0.98 to 1.59). COPD was significantly associated with the odds for increased risk of lung cancer(pooled OR=1.46;95%CI=1.04 to 2.03)

so were chronic bronchitis(OR =1.64;95% CI =1.15 to 2.36) and emphysema(OR=1.47;95%CI=1.17 to 1.83). Conclusion:The morbidity of COPD is probably associated with lung cancer smoking.

关键词

肺癌慢性阻塞性肺疾病Meta分析

Keywords

lung cancerchronic obstructive pulmonary diseasesMeta analysis

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