Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2

Zeng Dan; Zhou Weikang; Li Hui; Wu Yin; Lin Lan

doi:10.13406/j.cnki.cyxb.000799

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Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2

更新时间：2024-01-17

- Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2
- Journal of Chongqing Medical University Vol. 40, Issue 12, Pages: 1550-1554(2015)
- 作者机构：
  
  1. 重庆医科大学附属第一医院皮肤科
  2. 重庆市第三人民医院过敏反应科
  3. 重庆市急救中心皮肤科
  4. 重庆市中山医院皮肤科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000799
  CLC： R275.9
- Published：2015，
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[1]曾丹,周维康,李惠,吴音,林岚.四物消风散加减治疗慢性湿疹的疗效观察及对慢性湿疹患者TH1/TH2平衡的影响[J].重庆医科大学学报,2015,40(12):1550-1554.

Zeng Dan, Zhou Weikang, Li Hui, et al. Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2. [J]. Journal of Chongqing Medical University 40(12):1550-1554(2015)
[1]曾丹,周维康,李惠,吴音,林岚.四物消风散加减治疗慢性湿疹的疗效观察及对慢性湿疹患者TH1/TH2平衡的影响[J].重庆医科大学学报,2015,40(12):1550-1554. DOI： 10.13406/j.cnki.cyxb.000799.

Zeng Dan, Zhou Weikang, Li Hui, et al. Clinical effects of modified Siwu Xiaofeng powder in treating chronic eczema patients and its impact on the balance of TH1/TH2. [J]. Journal of Chongqing Medical University 40(12):1550-1554(2015) DOI： 10.13406/j.cnki.cyxb.000799.

摘要

目的:观察四物消风散加减治疗慢性湿疹的疗效及其对慢性湿疹患者TH1/TH2平衡的影响。方法:将纳入试验的患者随机分为治疗组和对照组

治疗组36例

对照组36例

治疗组用中药四物消风散加减

对照组口服盐酸非索非拉定

比较2组患者在治疗2周及4周的疗效;治疗前后检测外周血细胞因子IFN-γ、IL-4以及T-bet/GATA3的水平。结果:2组总有效率在第2周时分别为63.9%、38.9%

治疗组明显优于对照组;在第四周时分别为83.3%、61.1%

治疗组有效率明显高于对照组

2组比较差异有统计学意义（t=4.662

P=0.031）。治疗组、对照组在治疗后细胞因子IFN-γ、T-bet/GATA3较治疗前明显升高

IL-4较治疗前下降;治疗组细胞因子IFN-γ、IL-4及转录因子T-bet/GATA3的变化明显优于对照组

2组比较差异有统计学意义（t=15.31、10.64、8.68

P=0.001、0.002、0.004）。2组用药过程中均无明显不良反应。结论:中药四物消风散加减治疗慢性湿疹有效

其机理可能是通过调节IFN-γ、IL-4的水平

同时影响转录因子T-bet/GATA3的比值

恢复TH1/TH2平衡。

Abstract

Objective:To explore the curative effect of modified Siwu Xiaofeng powder on the chronic eczema

and its effect on the balance of TH1/TH2. Methods:Totally 75 cases are divided into treatment group and control group by random number table. The patients in treatment group received modified Siwu Xiaofeng powder for oral administration while those in control group were treated by Fexofenadine hydrochloride tablets. The clinical efficacy was compared at the second and fourth week after the treatment. The levels of IFN-γ

IL-4 and T-bet/GATA3 in peripheral blood were detected when all treatment is finished. Results:The total effective rate in treatment group and control group at two weeks after the treatment was 63.9% and 38.9%

respectively and that at four weeks after the treatment was 83.3% and 61.1%

respectively. The total effective rate in treatment group was significantly higher than that in control group

with statistical differences(t=4.662

P=0.031). The level of IFN-γ and the ratio of T-bet/GATA3 were increased both in therapy group and control group after the treatment

while the level of IL-4 was lower after the treatment than that before the treatment. The change of IFN-γ

IL-4 and T-bet/GATA3 in treatment group was better than that in the control group

with statistical differences(t=15.31

10.64

8.68;P=0.001

0.002

0.004). There was no obvious adverse reaction in both groups. Conclusion:Modified Siwu Xiaofeng powder is a effective treatment for chronic eczema

and it may resort TH1/TH2 balance via regulation of the level of IFN-γ

IL-4 and transcription factors T-bet /GATA3 ratio.

关键词

四物消风散慢性湿疹细胞因子Th1/Th2T-bet/GATA3

Keywords

Siwu Xiaofeng powderChronic eczemacytokinesTh1/Th2T-bet/GATA3

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