Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm

Du Jun; Wang Yonghong; Li Yongqiang

doi:10.13406/j.cnki.cyxb.000782

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Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm

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- Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm
- Journal of Chongqing Medical University Vol. 41, Issue 1, Pages: 61-64(2016)
- 作者机构：
  
  重庆医科大学附属第一医院神经内科、重庆市神经病学重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000782
  CLC： R743
- Published：2016，
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[1]杜君,王永红,李永强.颅内动脉瘤患者中性粒细胞与淋巴细胞比值和Hunt-Hess分级的相关性分析[J].重庆医科大学学报,2016,41(01):61-64.

Du Jun, Wang Yonghong, Li Yongqiang. Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm. [J]. Journal of Chongqing Medical University 41(1):61-64(2016)
[1]杜君,王永红,李永强.颅内动脉瘤患者中性粒细胞与淋巴细胞比值和Hunt-Hess分级的相关性分析[J].重庆医科大学学报,2016,41(01):61-64. DOI： 10.13406/j.cnki.cyxb.000782.

Du Jun, Wang Yonghong, Li Yongqiang. Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm. [J]. Journal of Chongqing Medical University 41(1):61-64(2016) DOI： 10.13406/j.cnki.cyxb.000782.

摘要

目的 :检测颅内动脉瘤患者中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio

NLR）水平

探索其联合HuntHess分级对颅内动脉瘤患者临床状态的评估价值。方法 :选取颅内动脉瘤患者220例

其中破裂颅内动脉瘤（ruptured intracranial aneurysm

RIA）组127例、未破裂颅内动脉瘤（unruptured intracranial aneurysm

UIA）组93例

应用静脉血中性粒细胞绝对值与淋巴细胞绝对值的比值表示NLR

Hunt-Hess分级初步评估病情严重程度。测定不同Hunt-Hess分级NLR水平

对NLR与Hunt-Hess分级的关系采用Spearman’s rho相关分析。结果:RIA组NLR与UIA组相比明显增高（P=0.000）;Hunt-HessⅠ

Ⅴ

级组NLR均较0级组明显增高（P

0.05）

Ⅲ

Ⅴ

级组NLR均较Ⅰ

Ⅱ

级组明显增高（P

0.05）;而Ⅰ和Ⅱ级以及Ⅲ和Ⅳ级组间NLR相比差异均无统计学意义（P

0.05）;NLR与Hunt-Hess分级呈正相关（r=0.768

P=0.000）。结论 :外周血NLR可能与颅内动脉瘤破裂相关

Hunt-Hess分级联合NLR可能能更准确地综合评估颅内动脉瘤患者病情严重程度及预后。

Abstract

Objective:To investigate the peripheral blood of neutrophil to lymphocyte ratio(NLR)levels in patients with intracranial aneurysm(IA)and to assess the risk of IA with the combination of Hunt-Hess grade and NLR. Methods:Totally 220 patients in our hospital from January 2014 to May 2015 were selected in the study and were divided into two groups:127 in ruptured intracranial aneurysm(RIA)group and 93 in unruptured intracranial aneurysm(UIA)group according to rupture. White blood cell(WBC)and its subtypes were obtained from venous blood. NLR was computed by taking the absolute neutrophil count and NLR was divided by the absolute lymphocyte count. The severity of IA was preliminarily evaluated using the Hunt-Hess grade. NLR in the six grades were measured. Correlation between NLR and Hunt-Hess grade was analyzed by Spearman ’s rho correlation analysis. Results:Clinical characteristics were comparable between the two groups(P >0.05). Compared with those of the UIA group

both WBC and NLR in the RIA were significantly higher(P=0.000

P=0.000). Compared with those in Hunt-Hess 0 grade

NLR in Ⅰ-Ⅴ were increased and NLR in Hunt-Hess Ⅲ-Ⅴ grades were higher than those in Ⅰ-Ⅱ grades

respectively(P<0.05). NLR was positively correlated with HuntHess grade(r=0.768

P=0.000). Conclusion:NLR might be associated with the rupture risk of IA;combination of Hunt-Hess grade and NLR might assess the severity of IA and predict its prognosis accurately.

关键词

颅内动脉瘤白细胞中性粒细胞与淋巴细胞比值Hunt-Hess分级

Keywords

intracranial aneurysmwhite blood cellneutrophil to lymphocyte ratioHunt-Hess grade

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Related Institution

Department of Clinical Laboratory，Qianjiang Hospital Affiliated to Chongqing University

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Department of Neurosurgery,The First Affiliated Hospital of Chongqing Medical University

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