Clinical analysis of dermatomyositis/polymyositis complicated with lung disease

Chen Hao; Jiang Tao; Zhou Mi; Xu Wu; Chen Nie

doi:10.13406/j.cnki.cyxb.000770

您当前的位置：

首页 >

文章列表页 >

Clinical analysis of dermatomyositis/polymyositis complicated with lung disease

更新时间：2024-01-17

- Clinical analysis of dermatomyositis/polymyositis complicated with lung disease
- Journal of Chongqing Medical University Vol. 40, Issue 12, Pages: 1546-1550(2015)
- 作者机构：
  
  重庆医科大学附属第一医院呼吸内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000770
  CLC： R593.2
- Published：2015，
扫描看全文
[1]陈豪,江涛,周蜜,徐武,陈聂.皮肌炎/多发性肌炎并发肺部疾病的临床分析[J].重庆医科大学学报,2015,40(12):1546-1550.

Chen Hao, Jiang Tao, Zhou Mi, et al. Clinical analysis of dermatomyositis/polymyositis complicated with lung disease. [J]. Journal of Chongqing Medical University 40(12):1546-1550(2015)
[1]陈豪,江涛,周蜜,徐武,陈聂.皮肌炎/多发性肌炎并发肺部疾病的临床分析[J].重庆医科大学学报,2015,40(12):1546-1550. DOI： 10.13406/j.cnki.cyxb.000770.

Chen Hao, Jiang Tao, Zhou Mi, et al. Clinical analysis of dermatomyositis/polymyositis complicated with lung disease. [J]. Journal of Chongqing Medical University 40(12):1546-1550(2015) DOI： 10.13406/j.cnki.cyxb.000770.

摘要

目的:总结分析皮肌炎（dermatomyositis

DM）和多发性肌炎（polymyositis

PM）并发肺部疾病种类及其各自的临床特征。方法:选取2011年1月至2014年11月在重庆医科大学附属第一医院住院治疗的54例DM/PM并发肺部疾病的患者作为研究对象

回顾性分析研究对象的一般情况、临床表现、实验室检查、肺功能、影像学检查、治疗及预后。结果:DM/PM并发肺部疾病以间质性肺病（interstitial lung disease

ILD）最常见

多表现为咳嗽、气促

血沉、C反应蛋白、肌酸激酶及铁蛋白升高、抗Jo-1抗体阳性在并发ILD患者中发生率高

肺功能异常主要表现为弥散伴限制性通气功能障碍

胸部CT检查以磨玻璃影最多见;DM/PM并发肺癌患者的皮肤损害明显

如皮肤血管炎、恶性红斑

80%患者肌酸激酶异常升高、抗Jo-1抗体阴性;DM/PM并发纵隔气肿是少见但严重的并发症

66.7%患者有明显的皮肤血管炎

所有患者均为青年男性

肌酸激酶较低

血沉升高

抗Jo-1抗体为阴性。结论:DM/PM患者并发肺部疾病与相应的炎性及免疫指标相关。

Abstract

Objective:To analyze the species and clinical features of dermatomyositis(DM) and polymyositis(PM) complicated with lung diseases. Methods:Totally 54 cases of hospitalized DM/PM patients with pulmonary disease

who are admitted to the First Affiliated Hospital of Chongqing Medical University from January 2011 to November 2014 were taken as the objects. The general condition

clinical manifestation

laboratory examination

pulmonary function

imaging

treatment and prognosis were retrospectively analyzed.Results:DM/PM complicated with interstitial lung disease(ILD) occurs most frequently

whose common symptoms are cough

shortness of breath

elevated erythrocyte sedimentation rate(ESR)

C-reactive protein(CRP)

creatine kinase(CK) and ferritin as well as positive anti-Jo-1 antibody;the abnormal lung function mainly displays as diffused and restrictive ventilatory dysfunction;ground glass is the most common sign in thoracic CT. Cutaneous vasculitis and malignant erythema are obvious in DM/PM complicated with lung cancer;80% patients has abnormally elevated CK and negative anti-Jo-1 antibody. DM/PM complicated with pneumomediastinum is a rare but serious complication;66.7% patients have significant skin vasculitis. All patients are young men

who have lower CK

increased ESR

negative anti-Jo-1 antibody. Conclusion :DM/PM patients complicated with lung disease are associated with corresponding inflammatory and immunological indexes.

关键词

皮肌炎多发性肌炎间质性肺病肺癌纵隔气肿

Keywords

dermatomyositispolymyositisinterstitial lung diseaselung cancerpneumomediastinum

references

Views

282

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mendelian randomization-based exploration of bidirectional causal relationship between gastroesophageal reflux disease and interstitial lung disease

Correlation between imaging characteristics and activity of interstitial lung disease in systemic lupus erythematosus

Effect of Glycyrrhiza uralensis Fisch. endophytes combined with cisplatin on proliferation and apoptosis of A549 cells

Establishment and validation prediction models of benign and malignant predictors for solitary pulmonary nodules

Effect of progressive muscle relaxation training on coping style and emotion of patients with lung cancer

Related Author

Zhang Jing

Li Fang

Lai Fang

Zhou Gengbiao

Tong Jiayin

Wang Si

Zhang Jingping

Hao Hui

Related Institution

Department of Critical Care Medicine，The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

The Second Clinical Medical College of Guangzhou University of Chinese Medicine

Department of Radiology,The First Affiliated Hospital of Xi’an Jiaotong University

Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence

College of Pharmacy，Gansu University of Chinese Medicine

⁰