Objective:To observe the influence of low intensity pulsed ultrasound(LIPUS) on chemotherapy-induced leucopenia and chemotherapy-induced thrombocytopenia by Ara-C in rabbit. Methods:Totally 28 rabbits were divided randomly into normal group(n=8) and model group(n=20). Ara-C(50 mg/kg) was injected into rabbits in model group from the ear vein for 3 days. Then rabbits in model group were randomized into LIPUS group(n=10

0.2 W/cm2

0.6 MHz) and control group(n=10);the cell number of white blood cell(WBC)

platelet(PLT)

NE

LY

MO and thromboxane(TXB2) were counted. Results:(1)The cell number of WBC and PLT of rabbits in model group decreased after Ara-C injection(t=10.770

P=0.000;t=6.751

P=0.000).(2)The cell number of WBC and NE of rabbits in LIPUS group increased compared with that of control group from 5th day after treatment(P=0.017;P=0.028);the cell number of LY of rabbits in LIPUS group increased from 3th day after treatment

but there was no significant difference compared that of with normal and control group(P=0.304;P=0.519). The cell number of MO of rabbits in LIPUS group were fluctuated

but there was no significant difference compared with that of control group(P =0.926;P =0.855;P =0.858;P =0.255;P =0.760;P =0.746;P =0.644).(3)The cell number of PLT of rab bits in LIPUS group were fluctuated

and there was no significant difference compared with that of control group(P=0.198;P=0.610;P=0.021;P=0.291;P=0.465;P=0.777;P=0.008).(4)There was no significant difference in the serum TXB2 levels of rabbits between control group and LIPUS group(P=0.725;P=0.096).(5)The nucleated cells number of bone marrow were increased. The skin and muscle had not been seen abnormal after treatment. Conclusion : LIPUS could increase the cell number of WBC

which may be related with its increase of cell number of NE. LIPUS had no effect on the number of platelets and the serum TXB2.