Objective:To explore the difference of myometrial apparent diffusion coefficient（ADC） values in corpus and cervix uteri of healthy women from menopausal phase to reproductive phase（proliferating phase

secretory phase）. Methods:Totally of 90 healthy women（30 in menopausal phase

30 in proliferating phase

30 in secretory phase） underwent MRI and ADC values were measured and compared at the corpus and cervix. Results :There were statistical significant differences in myometrial ADC values of corpus uteri during the menopausal phase [（1.23 ±0.31） ×10

-3

mm

2

/s]

secretory phase [（1.86 ±0.13） ×10

-3

mm

2

/s] and proliferating phase[（1.72±0.18）×10

-3

mm

2

/s]（F=67.300

P=0.000）. Statistical significant difference of myometrial ADC values had also been found in cervix during the menopausal phase [（1.19±0.37）×10

-3

mm

2

/s]

secretory phase[（1.82±0.18）×10

-3

mm

2

/s] and proliferating phase [（1.68±0.16）×10

-3

mm

2

/s]（F=47.890

P=0.000）. However no statistical difference of myometrial ADC values was found between the corpus and the cervix of uterus in menopausal phase

proliferating phase and secretory phase（all P

>

0.05）. The myometrial ADC values of corpus and cervix uteri in menopausal phase were significantly lower than those in proliferating phase and secretory phase（both P

<

0.05）

and myometrial ADC values of corpus and cervix uteri in proliferating phase were significantly lower than those in secretory phase（P

<

0.05）. Conclusion:The myometrial ADC values of healthy women could be affected by the physiological cycle

but not different regions of uterus

so variation of physiological cycle should be taken into consideration when evaluating the myometrial diseases

and accuracy of diseases diagnosis and differential diagnosis could be improved.