Relationship between the Keap1-Nrf2 system and mitochondria

Yuan Shenjun; Yuan Qin; Chen Tao

doi:10.13406/j.cnki.cyxb.000746

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Relationship between the Keap1-Nrf2 system and mitochondria

更新时间：2024-01-17

- Relationship between the Keap1-Nrf2 system and mitochondria
- Journal of Chongqing Medical University Vol. 42, Issue 11, Pages: 1370-1374(2017)
- 作者机构：
  
  1. 三峡大学第一临床医学院、宜昌市中心人民医院
  2. 三峡大学附属仁和医院
  3. 三峡大学医学院中医系国家中医药(肿瘤)管理局三级实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000746
  CLC： R346
- Published：2017，
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Yuan Shenjun, Yuan Qin, Chen Tao. Relationship between the Keap1-Nrf2 system and mitochondria. [J]. Journal of Chongqing Medical University 42(11):1370-1374(2017)
DOI：

Yuan Shenjun, Yuan Qin, Chen Tao. Relationship between the Keap1-Nrf2 system and mitochondria. [J]. Journal of Chongqing Medical University 42(11):1370-1374(2017) DOI： 10.13406/j.cnki.cyxb.000746.

摘要

当机体受到亲电子物质或活性氧刺激时

核转录相关因子2(nuclear factor erythroid-2 related factor 2

Nrf2)能诱导出一系列的保护性蛋白

从而抵抗内源性或外源性氧化应激造成的损害。越来越多的研究发现

某些组织比如心脏受到氧化应激时

Nrf2的活性和线粒体生物合成有关。在Surfeit 1蛋白(Surfeit locus protein 1

Surf1)突变的小鼠心脏中发现

由于细胞色素C氧化酶的缺乏导致细胞呼吸减少从而激活Nrf2。本文从Kelch样环氧氯丙烷相关蛋白1(Kelch-like ECH-associated protein-1

Keap1)-Nrf2通路与线粒体的关系以及氧化应激条件下Nrf2信号通路与线粒体之间的信号交联为重点进行了综述。

Abstract

Nrf2 is known to induce the expression of hundreds of cytoprotective proteins to counteract endogenously or exogenously generated oxidative stress when the body was stimulated by electrophilic reagents or reactive oxygen species. Interestingly

increasing evidence shows that Nrf2 is associated with mitochondrial biogenesis during environmental stresses in certain tissues such as the heart. Furthermore

Nrf2 activation was recently observed in the heart of surfeit locus protein 1（Surf1）-/-mice in which cellular respiration was decreased due to cytochrome c oxidase defects. In this review

we critically examine the relationship between Nrf2 and mitochondria

and argue that the Nrf2 stress pathway intimately communicates with mitochondria to maintain cellular homeostasis during oxidative stress.

关键词

核转录相关因子2Kelch样环氧氯丙烷相关蛋白1线粒体交联

Keywords

nuclear factor erythroid-2 related factor 2Kelch-like ECH-associated protein-1mitochondriacrosstalk

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Department of Cardiology,the Second Affiliated Hospital of Nanchang University

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重庆医科大学临床学院内科

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