Progress in micro RNA and renal fibrosis

Ke Ben; Wu Xianfeng; Fang Xiangdong

doi:10.13406/j.cnki.cyxb.000740

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Progress in micro RNA and renal fibrosis

更新时间：2024-01-17

- Progress in micro RNA and renal fibrosis
- Journal of Chongqing Medical University Vol. 41, Issue 3, Pages: 311-313(2016)
- 作者机构：
  
  南昌大学第二附属医院肾内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000740
  CLC： R692.5
- Published：2016，
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[1]柯本,吴险峰,房向东.MicroRNA在肾纤维化中的意义[J].重庆医科大学学报,2016,41(03):311-313.

Ke Ben, Wu Xianfeng, Fang Xiangdong. Progress in micro RNA and renal fibrosis. [J]. Journal of Chongqing Medical University 41(3):311-313(2016)
[1]柯本,吴险峰,房向东.MicroRNA在肾纤维化中的意义[J].重庆医科大学学报,2016,41(03):311-313. DOI： 10.13406/j.cnki.cyxb.000740.

Ke Ben, Wu Xianfeng, Fang Xiangdong. Progress in micro RNA and renal fibrosis. [J]. Journal of Chongqing Medical University 41(3):311-313(2016) DOI： 10.13406/j.cnki.cyxb.000740.

摘要

MicroRNA（miRNA）是内源性非编码短RNA

它通过在转录之前抑制靶m RNA达到抑制基因表达的能力。在肾脏中

miRNA与肾脏病变、稳态及生理功能等紧密相连。临床与动物实验均证明

miRNA在肾病的发病机制中起着重要作用。转录生长因子β（transforming growth factor-β

TGF-β）

由于其能刺激细胞外基质（extracellular matrix

ECM）的沉积损害正常肾脏功能

被认为是导致肾纤维化重要的介质之一。大量证据表明在肾脏疾病中

TGF-β信号通路与miRNA的表达有着密切联系。肾病患者血液及尿液中miRNA的出现已作为侦测肾脏疾病的早期生物标记物。慢性肾脏病动物模型的实验研究也表明

靶向miRNA在治疗肾脏疾病中有着巨大的潜在价值。因此研究miRNA在肾纤维化中的作用也许能为临床早期诊断及治疗肾脏疾病提供新方法。

Abstract

MicroRNAs(miRNAs)are endogenous short non-coding RNAs that regulate most of important cellular processes by inhibiting gene expression through the post-transcriptional repression of their target m RNAs. In kidneys

miRNAs have been associated with renal development

homeostasis

and physiological functions. Results from clinical and experimental animal studies demonstrate that miRNAs play essential roles in the pathogenesis of various renal diseases. Transforming growth factor-β(TGF-β)is recognized as a major mediator of renal fibrosis because it is able to stimulate the accumulation of extracellular matrix(ECM)proteins to impair normal kidney function. Recently

substantial evidences demonstrate the relationship between TGF-β signaling and miRNAs expression during renal diseases. Clinically

the presence of miRNAs in blood and urine has been examined to be early biomarkers for detecting renal diseases. From experimental animal studies of CKD

targeting micro RNAs also provides evidences about therapeutic potential of miRNAs during renal diseases. Therefore

determining the function of miRNAs and TGF-β in renal fibrosis may facilitate the development of both early diagnosis and of renal diseases.

关键词

microRNA肾脏疾病肾纤维化转录生长因子β信号通路

Keywords

microRNAKidney diseaserenal fibrosistransforming growth factor-β(TGF-β)signaling

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