Efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging

Tian Yi; Zhang Wenhong; Jin Lan

doi:10.13406/j.cnki.cyxb.000725

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Efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging

更新时间：2024-01-17

- Efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging
- Journal of Chongqing Medical University Vol. 40, Issue 12, Pages: 1558-1562(2015)
- 作者机构：
  
  重庆医科大学附属第二医院整形美容科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000725
  CLC： R62
- Published：2015，
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[1]田怡,张文红,金岚.1540nm非剥脱性点阵激光联合A型肉毒素改善眶周皮肤老化的疗效评价[J].重庆医科大学学报,2015,40(12):1558-1562.

Tian Yi, Zhang Wenhong, Jin Lan. Efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging. [J]. Journal of Chongqing Medical University 40(12):1558-1562(2015)
[1]田怡,张文红,金岚.1540nm非剥脱性点阵激光联合A型肉毒素改善眶周皮肤老化的疗效评价[J].重庆医科大学学报,2015,40(12):1558-1562. DOI： 10.13406/j.cnki.cyxb.000725.

Tian Yi, Zhang Wenhong, Jin Lan. Efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging. [J]. Journal of Chongqing Medical University 40(12):1558-1562(2015) DOI： 10.13406/j.cnki.cyxb.000725.

摘要

目的:观察1 540 nm非剥脱性点阵激光联合A型肉毒素改善眶周皮肤老化的临床疗效。方法:将186例求美者随机分为3组:联合治疗组（62例）

注射对照组（62例）和激光对照组（62例）。联合治疗组与注射对照组采用A型肉毒素进行1次注射。2周后

联合治疗组与激光对照组均使用1 540 nm非剥脱性点阵激光治疗3次

每次间隔4周。随访26周。由医师及求美者对其静态和动态的眶周皱纹分别进行客观评价及满意度打分。结果:3组求美者眶周皮肤老化均得到改善。第1次治疗后早期第4周

联合治疗组的总有效率和满意度与注射对照组无明显差异（动态皱纹χ

=0.100

P=0.752;静态皱纹χ

=1.125

P=0.289;满意度χ

=1.554

P=0.213）

与激光对照组有差异（动态皱纹χ

=68.903

P=0.000;静态皱纹χ

=25.966

P=0.000;满意度χ

=57.441

P=0.000）;治疗后期第26周时联合治疗组的总有效率和满意度与注射对照组明显差异（动态皱纹χ

=57.597

P=0.000;静态皱纹χ

=71.925

P=0.000;满意度χ

=64.882

P=0.000）

而与激光对照组无明显差异（动态皱纹χ

=0.152

P=0.697;静态皱纹χ

=0.043

P=0.836;满意度χ

=0.168

P=0.681）。结论:1 540 nm非剥脱性点阵激光联合A型肉毒素改善眶周皮肤老化

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Abstract

Objectives:To observe the clinical efficacy of 1 540 nm non-ablative fractional laser combined with botulinum toxin type A in improvement of periorbital skin aging. Methods:Totally 186 patients were randomly divided into three groups. Patients in combined treatment group(62 cases) and injection control group(62 cases) were injected botulinum toxin A for one time. After two weeks

124 cases including those in combined treatment group and laser control group were taken 1 540 nm non-ablative fractional laser for3 times

with interval of 4 weeks. Follow-up was conducted for 6 weeks after the first treatment. Subjective and objective assessment on the periorbital dynamic and static wrinkles were made by doctors and cosmetic patients. Results:The periorbital skin aging of three groups were all improved. The improvement was more obvious in combined group than in laser control group at 4 weeks after the first treatment

while no significant difference was found between combined group and injection control group. After 26 weeks of the first treatment

the improvement was more obvious in combined group than in injection control group

and no significant difference was found between combined group and laser control group. Conclusion:Combination of non-ablative 1 540 nm fractional laser and botulinum toxin type A is effective and safe in the treatment of periorbital skin aging.

关键词

皮肤老化非剥脱性1 540 nm点阵激光A型肉毒素

Keywords

skin agingnon-ablative fractional laserbotulinum toxin type A

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