MR T<sub>1</sub> fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo

Liu Yingjiang; Zhang Lian; Xiao Zhibo; Peng Song; Shui Lian; Wang Zhibiao; Lyu Fajin

doi:10.13406/j.cnki.cyxb.000719

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MR T₁ fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo

更新时间：2024-01-17

- MR T₁ fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo
- Journal of Chongqing Medical University Vol. 40, Issue 12, Pages: 1515-1519(2015)
- 作者机构：
  
  1. 重庆医科大学生物医学工程学院省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室
  2. 重庆医科大学附属第一医院放射科
  3. 四川省绵阳市404医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000719
  CLC： R445.2
- Published：2015，
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[1]刘映江,张炼,肖智博,彭松,税莲,王智彪,吕发金.磁共振T_1 fl2d监控高强度聚焦超声消融的可行性研究[J].重庆医科大学学报,2015,40(12):1515-1519.

Liu Yingjiang, Zhang Lian, Xiao Zhibo, et al. MR T₁ fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo. [J]. Journal of Chongqing Medical University 40(12):1515-1519(2015)
[1]刘映江,张炼,肖智博,彭松,税莲,王智彪,吕发金.磁共振T_1 fl2d监控高强度聚焦超声消融的可行性研究[J].重庆医科大学学报,2015,40(12):1515-1519. DOI： 10.13406/j.cnki.cyxb.000719.

Liu Yingjiang, Zhang Lian, Xiao Zhibo, et al. MR T₁ fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo. [J]. Journal of Chongqing Medical University 40(12):1515-1519(2015) DOI： 10.13406/j.cnki.cyxb.000719.

摘要

目的:探讨磁共振T

fl2d序列监控高强度聚焦超声消融的可行性。方法:在磁共振引导的高强度聚焦超声消融离体牛肝组织过程中

使用磁共振T

加权二维小角度激发快速梯度回波（T

weighted fast low-angle shot two-dimensional gradient-echo sequence

fl2d）序列扫描辐照焦点及周边区域的信号变化

将信号变化率分为5个范围:

15%、

20%、

25%、

30%、

35%

将这5个范围对应的面积分别与实际凝固性坏死的面积进行比较

找出当组织发生凝固性坏死时对应的信号变化率。为了初步验证该方法的可行性

将此结果应用于T1fl2d监控辐照活体兔腿肌肉组织的过程中

比较这一信号变化率对应的面积与增强扫描无强化区的面积

观察其在活体组织中应用的情况。结果:超声消融新鲜离体牛肝组织28个点

当靶区信号变化率大于25%时

其面积为（79.17±21.80）mm2

对应牛肝组织的实际凝固性坏死面积为（81.45±15.45）mm2

二者间差异无统计学意义（t=0.758

P=0.455）;当靶区信号变化率大于15%、20%、30%和35%时

其分别对应的面积与牛肝实际凝固性坏死面积比较

差异均有显著性

P值均小于0.05。超声消融活体兔腿15个点

增强扫描无强化区面积（72.21±18.51）mm2

信号变化率大于25%时对应的面积为（74.25±24.45）mm2

二者间差异无统计学意义（t=0.664

P=0.517）。结论:使用磁共振T1fl2d序列监控高强度超声消融是可行的。

Abstract

Objective:To evaluate the feasibility of using a T

fl2 d to monitor a high-intensity focused ultrasound（HIFU） ablation procedure in ex vivo/in vivo experiments. Methods:HIFU ablations in cow’s liver（ex vivo） and rabbit leg muscle（in vivo） were monitored with a T

weighted fast low-angle shot two-dimensional（T

fl2d） sequence. The ex vivo experiment aimed to demonstrate the relationship between changes in signal magnitude and necrosis. During sonication

the changes in the signal magnitude was calculated and divided into five ranges:

15%

20%

25%

30%

and

35%. The area corresponding to these five ranges and the actual area of coagulative necrosis were compared to find signal variation rate. Then

the feasibility of using T

fl2d-based monitoring in vivo was studied during HIFU ablations in rabbit leg muscle. The area corresponding to the signal variation rate and the area of nonperfusion on the contrast-enhanced MR image were compared to observe the application of T

fl2d-based monitoring in vivo. Results:For the ex vivo HIFU experiment

28 sonicated sites were obtained;only when the signal variation rate was greater than 25%

there was no significant difference between the corresponding area of（79.17±21.80） mm2 and the actual area of coagulative necrosis of（81.45 ±15.45） mm2（t =0.758

P =0.455）. As expected

15 sonicated sites were obtained in vivo rabbit leg muscle experiments

the area of nonperfusion on the enhanced image was（72.21±18.51） mm2

and the area with a signal variation rate greater than 25% was（74.25±24.45） mm2

without significant differences between the two areas（t=0.664

P=0.517）. Conclusion:The use of a T

fl2 d to monitor HIFU ablation procedures in ex vivo/in vivo experiments is feasible

and this approach may have potential applications in clinical treatment.

关键词

磁共振成像高强度聚焦超声消融磁共振信号

Keywords

magnetic resonance imaginghigh-intensity focused ultrasoundmagnetic resonance magnitude signal

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MR T1 fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo

DOI：10.13406/j.cnki.cyxb.000719

摘要

Abstract

关键词

Keywords

references

MR T₁ fl2d for guidance of high-intensity focused ultrasound ablation:an experimental study ex vivo /in vivo