Expression and significance of FOXP3 in colon cancer cells

Qiu Lei; Shao Hua; Miao Yongchang

doi:10.13406/j.cnki.cyxb.000677

您当前的位置：

首页 >

文章列表页 >

Expression and significance of FOXP3 in colon cancer cells

更新时间：2024-01-17

- Expression and significance of FOXP3 in colon cancer cells
- Journal of Chongqing Medical University Vol. 40, Issue 11, Pages: 1438-1440(2015)
- 作者机构：
  
  连云港市第二人民医院胃肠外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000677
  CLC： R735.35
- Published：2015，
扫描看全文
[1]邱磊,邵华,苗永昌.FOXP3在结肠癌癌细胞中的表达及临床意义[J].重庆医科大学学报,2015,40(11):1438-1440.

Qiu Lei, Shao Hua, Miao Yongchang. Expression and significance of FOXP3 in colon cancer cells. [J]. Journal of Chongqing Medical University 40(11):1438-1440(2015)
[1]邱磊,邵华,苗永昌.FOXP3在结肠癌癌细胞中的表达及临床意义[J].重庆医科大学学报,2015,40(11):1438-1440. DOI： 10.13406/j.cnki.cyxb.000677.

Qiu Lei, Shao Hua, Miao Yongchang. Expression and significance of FOXP3 in colon cancer cells. [J]. Journal of Chongqing Medical University 40(11):1438-1440(2015) DOI： 10.13406/j.cnki.cyxb.000677.

摘要

目的:研究叉头样螺旋转录因子（transcription factor forkhead box P3

FOXP3）在结肠癌癌细胞中的表达及其与总生存率（overall survival rate

OS）的关系。方法:采用组织芯片及免疫组化技术检测90例原发性结肠腺癌癌细胞FOXP3的表达

分析其临床意义。结果:结肠癌癌细胞表达FOXP3（+）的病例较癌细胞FOXP3（-）的病例预后差（χ2=4.427

P=0.035）;淋巴结阳性组癌细胞FOXP3阳性率高于淋巴结阴性组（χ2=11.244

P=0.000）;TNM分期越早癌细胞FOXP3阳性率越低（χ2=7.603

P=0.006）。结论:结肠癌癌细胞表达FOXP3（+）可能是结肠癌预后的一个独立危险因素。

Abstract

Objective:To investigate the relationship between transcription factor forkhead box P3(FOXP3)cells in colon cancer and overall survival(OS). Methods:The FOXP3 cells was detected by tissue microarray and immunohistochemistry staining technique to evaluate the prognostic effects. Paraffin blocks of operation resection of primary adenocarinoma of colon were obtained from ninety patients. Results:Colon carcinoma cells expressing FOXP3(+)had poorer prognosis than those expressing FOXP3(-)(χ2=4.427

P=0.035). The frequency of the presence of FOXP3(-)positive cancer cells was higher in patients with lymphatic invasion(χ2=11.244

P=0.000)and lower in patients with early TNM stage(χ2=7.603

P=0.006). Conclusion:Colon carcinoma cell expressing FOXP3(+)is a promising independent predictor for OS in colon carcinoma.

关键词

结肠癌叉头样螺旋转录因子免疫组织化学组织芯片

Keywords

colon carcinomatranscription factor forkhead box P3immunohistochemistrytissue microarray

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics

Expression of HIF-1α and Sema4D in pancreatic carcinoma and its clinical significance

HISTOCHEMICAL AND IMMUNOHISTOCHEMI- CAL STUDY OF MAMMAKY PAGET’S DISEASE

THE EXPRESSION AND SIGMFICANCE OF HMB45,S-100 PROTEIN AND VIMENTIN IN PRIMARY MALIGNANT MELANOMA

Histopathologic examination of uterine smooth muscle tumors

Related Author

JI Runyuan

SHI Enyi

WANG Yongshi

LI Xiaoning

ZHAO Yufang

FENG Zhenqing

Jia Rujiang

Yin Qingchen

Related Institution

Huaian Key Laboratory of the Tumor of Digestive System，Huaiyin Advanced Vocational and Technical Hygiene School

Department of Pathology，Jiangsu Province Suzhou Health College

Department of Pathology，Cancer Hospital of Huaian City

Department of Pathology，School of Basic Medical Sciences，Nanjing Medical University

Department of General Surgery,Handan Central Hospital

⁰