Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma

ZHANG Jun-xiu; QI Shuai; GAO Lei

doi:10.11659/jjssx12E022113

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Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma

Clinical Research | 更新时间：2024-01-22

- Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 1, Pages: 76-79(2024)
- 作者机构：
  
  1.保定市儿童医院皮肤科，河北保定 071000
  2.石家庄市栾城人民医院普外科，河北石家庄 051430
  3.保定市第一医院皮肤科，河北保定 071066
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx12E022113
  CLC： R732.2
- Published：25 January 2024，
  
  Received：21 December 2022，
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张均秀,齐帅,高磊.马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床研究[J].局解手术学杂志,2024,33(01):76-79.

ZHANG Jun-xiu,QI Shuai,GAO Lei.Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(01):76-79.
张均秀,齐帅,高磊.马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床研究[J].局解手术学杂志,2024,33(01):76-79. DOI： 10.11659/jjssx12E022113.

ZHANG Jun-xiu,QI Shuai,GAO Lei.Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(01):76-79. DOI： 10.11659/jjssx12E022113.

摘要

目的

探究马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床效果。

方法

将240例皮肤血管瘤患儿随机分为对照组（120例）和联合组（120例），其中对照组患儿给予马来酸噻吗洛尔治疗，联合组患儿给予马来酸噻吗洛尔联合冷冻治疗。比较2组患儿临床疗效、瘤体直径、血清基质金属蛋白酶-9（MMP-9）水平、血管内皮生长因子（VEGF）水平及不良反应发生情况。

结果

联合组患儿治疗总有效率明显高于对照组（

0.05）。与治疗前比较，治疗后3个月、治疗后6个月2组患儿瘤体直径均逐渐减小（

0.05），且联合组患儿治疗后3个月、治疗后6个月瘤体直径减小更明显（

0.05）。与治疗前比较，治疗后3个月、治疗后6个月2组患儿血清MMP-9及VEGF水平均逐渐降低（

0.05），且联合组患儿治疗后3个月、6个月MMP-9及VEGF水平均明显低于对照组（

0.05）。2组患儿湿疹、溃疡、糜烂及红肿等不良反应总发生率比较，差异无统计学意义（

0.05）。

结论

马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤疗效显著，可有效降低血清MMP-9、VEGF水平，缩小瘤体，安全有效。

Abstract

Objective

To explore the clinical effect of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma.

Methods

A total of 240 infants with cutaneous hemangioma were randomly divided into the control group （120 cases） and the combined group （120 cases）. The control group was treated with timolol maleate， and the combined group was treated with timolol maleate combined with cryotherapy. The clinical efficacy， tumor diameter， levels of serum matrix metalloproteinase-9 （MMP-9） and vascular endothelial growth factor （VEGF） and the occurrence of adverse reactions of the two groups were compared.

Results

The total effective rate of the combined group was significantly higher than that of the control group （

0.05）. Compared with before treatment， the tumor diameter 3 months and 6 months after treatment in the two groups gradually decreased （

0.05）， and the tumor diameter 3 months and 6 months after treatment in the combined group decreased more obviously （

0.05）. Compared with before treatment， the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the two groups gradually decreased （

0.05）， and the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the combined group were significantly lower than those in the control group （

0.05）. There was no statistically significant difference in the total incidence of adverse reactions such as eczema， ulcer， erosion or redness between the two groups （

0.05）.

Conclusion

Timolol maleate combined with cryotherapy for infantile cutaneous hemangioma has significant curative effect， which can effectively reduce the levels of serum MMP-9 and VEGF，and shrink the tumor body， with safety and effectiveness.

关键词

婴幼儿皮肤血管瘤冷冻疗法马来酸噻吗洛尔血管内皮生长因子基质金属蛋白酶-9

Keywords

infantile cutaneous hemangiomacryotherapytimolol maleatevascular endothelial growth factormatrix metalloproteinase-9

references

Kardasevic M，Dinarevic SM.Infantile sacral region hemangioma and combination treatment with propranolol and topical timolol：case review and reference review［J］.Med Arch，2021，75（2）：158.doi：10.5455/medarh.2021.75.158-161http://dx.doi.org/10.5455/medarh.2021.75.158-161.

Rodríguez Bandera AI，Sebaratnam DF，Wargon O，et al.Infantile hemangioma.Part 1：epidemiology，pathogenesis，clinical presentation and assessment［J］.J Am Acad Dermatol，2021，85（6）：1379-1392.doi：10.1016/j.jaad.2021.08.019http://dx.doi.org/10.1016/j.jaad.2021.08.019.

韦海莲，韦智晓，庞筱安，等.90Sr敷贴治疗头发部位婴幼儿血管瘤的疗效及治疗对发量的影响［J］.中华核医学与分子影像杂志，2021，41（12）：743-747.doi：10.3760/cma.j.cn321828-20210723-00248http://dx.doi.org/10.3760/cma.j.cn321828-20210723-00248.

赵菊花，庄化迪，王洁，等.噻吗洛尔滴眼液联合卤米松外敷治疗婴幼儿皮肤表浅型血管瘤［J］.西部医学，2020，32（5）：745-748.doi：10.3969/j.issn.1672-3511.2020.05.028http://dx.doi.org/10.3969/j.issn.1672-3511.2020.05.028.

李晓飞，陈峻江.普萘洛尔联合马来酸噻吗洛尔治疗不同分型婴幼儿血管瘤疗效观察［J］.陕西医学杂志，2020，49（4）：498-501.doi：10.3969/j.issn.1000-7377.2020.04.028http://dx.doi.org/10.3969/j.issn.1000-7377.2020.04.028.

黎胜苗，罗春芬，许嘉川，等.不同浓度马来酸噻吗洛尔滴眼液治疗浅表性婴幼儿血管瘤的临床研究［J］.组织工程与重建外科杂志，2020，16（3）：179-181.doi：10.3969/j.issn.1673-0364.2020.03.001http://dx.doi.org/10.3969/j.issn.1673-0364.2020.03.001.

罗丽芳，单孔荣，张武，等.冰醋酸与液氮冷冻治疗面部扁平疣的临床观察研究［J］.中国现代医生，2018，56（23）：78-80.

周金枝.液氮冷冻治疗跖疣面积变化及与预后关系的临床研究［J］.中西医结合心血管病电子杂志，2018，6（35）：74-75.doi：10.3969/j.issn.2095-6681.2018.35.055http://dx.doi.org/10.3969/j.issn.2095-6681.2018.35.055.

马琳.儿童皮肤病学［M］.北京：人民卫生出版社，2014：156-166.

Achauer BM，Chang CJ，Vander Kam VM.Management of hermangioma of infancy：review of 245 patients［J］.Plastl Reconstr Surg，1997，99（5）：1301-1308.doi：10.1097/00006534-199704001-00014http://dx.doi.org/10.1097/00006534-199704001-00014.

卢国坚.口服普萘洛尔联合聚桂醇局部注射治疗婴幼儿血管瘤的疗效评价［J］.中国麻风皮肤病杂志，2020，36（2）：80-82.doi：10.12144/zgmfskin202002080http://dx.doi.org/10.12144/zgmfskin202002080.

郑健敏，朱智胜，王朝阳，等.口服阿替洛尔对比口服普萘洛尔治疗婴幼儿血管瘤疗效及安全性的meta分析［J］.中华整形外科杂志，2022，38（3）：275-283.doi：10.3760/cma.j.cn114453-20210927-00394http://dx.doi.org/10.3760/cma.j.cn114453-20210927-00394.

侯梦，张银苹，刘秋雨，等.婴儿性血管瘤临床病理学特征［J］.中华病理学杂志，2021，50（5）：508-510.doi：10.3760/cma.j.cn112151-20201204-00901http://dx.doi.org/10.3760/cma.j.cn112151-20201204-00901.

Jin WW，Tong Y，Wu JM，et al.Observation on the effects of 595-nm pulsed dye laser and 755-nm long-pulsed alexandrite laser on sequential therapy of infantile hemangioma［J］.J Cosmet Laser Ther，2020，22（3）：159-164.doi：10.1080/14764172.2020.1783452http://dx.doi.org/10.1080/14764172.2020.1783452.

Guo L，Wu C，Song D，et al.Transcatheter arterial sclerosing embolization for the treatment of giant propranolol-resistant infantile hemangiomas in the parotid region［J］.J Vasc Interv Radiol，2021，32（2）：293-298.doi：10.1016/j.jvir.2020.09.029http://dx.doi.org/10.1016/j.jvir.2020.09.029.

郝明明.二氧化碳激光结合液氮冷冻治疗寻常疣临床效果观察［J］.中外医学研究，2020，18（4）：42-43.doi：10.14033/j.cnki.cfmr.2020.04.018http://dx.doi.org/10.14033/j.cnki.cfmr.2020.04.018.

吴美乐，吕新翔，于希军，等.液氮冷冻联合光动力疗法治疗男性包皮尖锐湿疣的疗效观察及HPV检测分析［J］.皮肤病与性病，2021，43（5）：640-642.doi：10.3969/j.issn.1002-1310.2021.05.012http://dx.doi.org/10.3969/j.issn.1002-1310.2021.05.012.

于倩，许鹏，黄惠真，等.单纯口服普萘洛尔与联合外用0.5%马来酸噻吗洛尔乳膏治疗婴幼儿血管瘤效果的随机对照研究［J］.中华整形外科杂志，2019，35（2）：137-141.doi：10.3760/cma.j.issn.1009-4598.2019.02.008http://dx.doi.org/10.3760/cma.j.issn.1009-4598.2019.02.008.

黄子芮，马建军，杨浩强，等.婴幼儿皮肤血管瘤的临床治疗及研究进展［J］.齐齐哈尔医学院学报，2021，42（21）：1906-1912.doi：10.3969/j.issn.1002-1256.2021.21.018http://dx.doi.org/10.3969/j.issn.1002-1256.2021.21.018.

张娅琴，雷智贤，黄婷，等.马来酸噻吗洛尔与普萘洛尔联合治疗婴幼儿表浅型血管瘤临床研究［J］.中国临床药理学杂志，2021，37（4）：362-365.doi：10.13699/j.cnki.1001-6821.2021.04.003http://dx.doi.org/10.13699/j.cnki.1001-6821.2021.04.003.

谭鑫，王高兴，王佳，等.氩氦刀并肝动脉介入治疗原发性肝癌及对血清VEGF及MMP的影响研究［J］.临床和实验医学杂志，2021，20（5）：493-496.doi：10.3969/j.issn.1671-4695.2021.05.012http://dx.doi.org/10.3969/j.issn.1671-4695.2021.05.012.

刘建中，邓霞，谭卫群，等.外用2%盐酸卡替洛尔和0.5%马来酸噻吗洛尔滴眼液治疗浅表性婴儿血管瘤临床观察［J］.中国皮肤性病学杂志，2021，35（3）：277-281.doi：10.13735/j.cjdv.1001-7089.202007183http://dx.doi.org/10.13735/j.cjdv.1001-7089.202007183.

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