Diagnostic significance of CK-MB, MYO and hs-cTnT for myocardial injury in patients with sepsis

WU Yong-hua; YAO Li-ying; SU Wei; LIU Du

doi:10.11659/jjssx.12E022017

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Diagnostic significance of CK-MB, MYO and hs-cTnT for myocardial injury in patients with sepsis

Clinical Research | 更新时间：2023-09-26

- Diagnostic significance of CK-MB, MYO and hs-cTnT for myocardial injury in patients with sepsis
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 9, Pages: 813-816(2023)
- 作者机构：
  
  1.电子科技大学医学院附属绵阳市中心医院医学检验科，四川绵阳 621000
  2.电子科技大学医学院附属绵阳市中心医院医务科，四川绵阳 621000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.12E022017
  CLC： R459.7
- Published：25 September 2023，
  
  Received：02 December 2022，
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吴泳桦,姚力偀,苏维等.CK-MB、MYO、hs-cTnT对脓毒症患者心肌损伤的诊断意义[J].局解手术学杂志,2023,32(09):813-816.

WU Yong-hua,YAO Li-ying,SU Wei,et al.Diagnostic significance of CK-MB, MYO and hs-cTnT for myocardial injury in patients with sepsis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(09):813-816.
吴泳桦,姚力偀,苏维等.CK-MB、MYO、hs-cTnT对脓毒症患者心肌损伤的诊断意义[J].局解手术学杂志,2023,32(09):813-816. DOI： 10.11659/jjssx.12E022017.

WU Yong-hua,YAO Li-ying,SU Wei,et al.Diagnostic significance of CK-MB, MYO and hs-cTnT for myocardial injury in patients with sepsis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(09):813-816. DOI： 10.11659/jjssx.12E022017.

摘要

目的

探讨血清肌酸激酶同工酶MB（CK-MB）、肌红蛋白（MYO）、高敏肌钙蛋白T（hs-cTnT）检测对脓毒症患者心肌损伤的诊断价值。

方法

选取我院收治的132例脓毒症患者，根据患者是否存在心肌损伤分为心肌损伤组（50例）和非心肌损伤组（82例），根据脓毒症患者心肌损伤严重程度分为轻度组（33例）和重度组（17例）。采用电化学发光法检测患者血清CK-MB、MYO、hs-cTnT水平；采用受试者工作特征（

ROC

）曲线分析血清CK-MB、MYO、hs-cTnT水平对脓毒症患者心肌损伤的诊断价值，计算灵敏度、特异度、曲线下面积（

AUC

）。

结果

心肌损伤组患者血清CK-MB、MYO、hs-cTnT水平均高于非心肌损伤组（

0.05）。重度组患者血清CK-MB、MYO、hs-cTnT水平均高于轻度组（

0.05）。

ROC曲线

结果显示，血清CK-MB、MYO、hs-cTnT联合检测诊断脓毒症患者心肌损伤的灵敏度和

AUC

均高于单独检测（

0.05）。

结论

脓毒症心肌损伤患者血清CK-MB、MYO、hs-cTnT水平升高，且心肌重度损伤患者以上指标水平均高于轻度损伤患者，检测血清CK-MB、MYO、hs-cTnT均对脓毒症患者心肌损伤有一定的诊断价值，而三者联合检测诊断价值更高。

Abstract

Objective

To investigate the diagnostic values of serum creatine kinase-MB （CK-MB）， myoglobin （MYO） and hypersensitive cardiac troponin T （hs-cTnT） detection for myocardial injury in patients with sepsis.

Methods

A total of 132 patients with sepsis admitted to our hospital were selected，and they were divided into the myocardial injury group （50 cases） and non-myocardial injury group （82 cases） according to whether the patients had myocardial injury，and sepsis patients with myocardial injury were divided into the mild group （33 cases） and severe group （17 cases） according to their severity.The levels of serum CK-MB，MYO and hs-cTnT of patients were detected by electrochemiluminescence assay. The diagnostic values of serum CK-MB，MYO and hs-cTnT levels on myocardial injury in patients with sepsis were analyzed by the

receiver operating characteristic

（

ROC

） curve，and the sensitivity， specificity and

area under the curve

（

AUC

） were calculated.

Results

The levels of serum CK-MB，MYO and hs-cTnT in the myocardial injury group were higher than those in the non-myocardial injury group （

0.05）.The levels of serum CK-MB，MYO and hs-cTnT in the severe group were higher than those in the mild group （

0.05）.

ROC

curve results showed that the sensitivity and

AUC

of combined detection of serum CK-MB，MYO and hs-cTnT to diagnose myocardial injury in patients with sepsis were higher than those of individual detection （

0.05）.

Conclusion

The levels of serum CK-MB， MYO and hs-cTnT are increased in sepsis patients with myocardial injury， and the levels of the above indicators in patients with severe myocardial injury were higher than those in patients with mild myocardial injury. The detections of serum CK-MB， MYO and hs-cTnT have certain diagnostic value for myocardial injury in patients with sepsis， and the diagnostic value of the combined detection is higher.

关键词

肌酸激酶同工酶MB肌红蛋白高敏肌钙蛋白T脓毒症心肌损伤

Keywords

creatine kinase-MBmyoglobinhypersensitive cardiac troponin Tsepsismyocardial injury

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