Research progress of α-synuclein in the pathogenesis of Parkinson's disease

LIU Ke-ting; HE Ze-min; YANG Bai-yuan; ZHONG Cheng-qing; GOU Wei; XIAO Li

doi:10.11659/jjssx.12E022006

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Research progress of α-synuclein in the pathogenesis of Parkinson's disease

Review | 更新时间：2023-12-13

- Research progress of α-synuclein in the pathogenesis of Parkinson's disease
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 12, Pages: 1091-1094(2023)
- 作者机构：
  
  1.成都市第七人民医院神经内科，四川成都 610213
  2.四川大学华西空港医院胸外科，四川成都 610200
  3.成都医学院人体解剖与组织胚胎学教研室/发育与再生四川省重点实验室，四川成都 610500
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.12E022006
  CLC： R742.5
- Published：25 December 2023，
  
  Received：01 December 2022，
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刘柯婷,贺泽民,杨百元等.α-突触核蛋白在帕金森病发病机制中的研究进展[J].局解手术学杂志,2023,32(12):1091-1094.

LIU Ke-ting,HE Ze-min,YANG Bai-yuan,et al.Research progress of α-synuclein in the pathogenesis of Parkinson's disease[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(12):1091-1094.
刘柯婷,贺泽民,杨百元等.α-突触核蛋白在帕金森病发病机制中的研究进展[J].局解手术学杂志,2023,32(12):1091-1094. DOI： 10.11659/jjssx.12E022006.

LIU Ke-ting,HE Ze-min,YANG Bai-yuan,et al.Research progress of α-synuclein in the pathogenesis of Parkinson's disease[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(12):1091-1094. DOI： 10.11659/jjssx.12E022006.

摘要

帕金森病（PD）是最常见的神经系统退行性疾病，路易小体（LBs）是其最典型的病理改变。LBs的主要成分是α-突触核蛋白（α-syn），其被认为是PD的致病因子。传递假说认为，病理性α-syn可由受损神经元转运到正常神经元，导致受体神经元中α-syn也产生病理性错误折叠和聚集，导致级联式神经细胞受损。肠脑轴假说认为，病理性α-syn可由肠道产生，经由迷走神经上传至中枢神经系统。本文就α-syn在PD发病机制中的作用进行概述，以期为PD的干预靶点的研究提供参考。

Abstract

Parkinson's disease（PD） is the most common neurodegenerative disease， and Lewy bodies （LBs） is the most typical pathological change. α-synuclein （α-syn）， as the main component of LBs， is considered as the pathogenic factor of PD. According to the transmission hypothesis， pathological α-syn can be transported from damaged neurons to normal neurons， leading to pathological misfolding and aggregation of α-syn in recipient neurons， resulting in cascading neuronal damage. According to the hypothesis of gut-brain axis， pathological α-syn can be produced in the intestine， and uploaded to the central nervous system via the vagus nerve. In this paper， the role of α-syn in the pathogenesis of PD is summarized， in order to provide reference for the study of intervention targets of PD.

关键词

帕金森病α-突触核蛋白肠脑轴

Keywords

Parkinson's diseaseα-synucleingut-brain axis

references

Braak H，Del Tredici K，Rüb U， et al.Staging of brain pathology related to sporadic Parkinson's disease［J］.Neurobiol Aging，2003，24（2）：197-211.doi：10.1016/s0197-4580（02）00065-9http://dx.doi.org/10.1016/s0197-4580（02）00065-9.

Moore K，Sengupta U，Puangmalai N， et al.Polymorphic Alpha-Synuclein Oligomers：characterization and differential detection with novel corresponding antibodies［J］.Mol Neurobiol，2023：1-15.doi：10.1007/s12035-023-03211-3http://dx.doi.org/10.1007/s12035-023-03211-3.

Gupta V，Salim S，Hmila I， et al.Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxi- city［J］.Sci Rep，2020，10（1）：8137.doi：10.1038/s41598-020-65035-8http://dx.doi.org/10.1038/s41598-020-65035-8.

Benskey MJ， Perez RG， Manfredsson FP.The contribution of alpha synuclein to neuronal survival and function - implications for Parkinson's disease［J］.J Neurochem，2016，137（3）：331-359.doi：10.1111/jnc.13570http://dx.doi.org/10.1111/jnc.13570.

Soto C，Pritzkow S.Protein misfolding，aggregation， and conformational strains in neurodegenerative diseases［J］.Nat Neurosci，2018，21（10）：1332-1340.doi：10.1038/s41593-018-0235-9http://dx.doi.org/10.1038/s41593-018-0235-9.

Sengupta U，Puangmalai N，Bhatt N， et al.Polymorphic α-Synuclein strains modified by Dopamine and docosahexaenoic acid interact differentially with Tau protein［J］.Mol Neurobiol，2020，57（6）：2741-2765.doi：0.1007/s12035-020-01913-6http://dx.doi.org/0.1007/s12035-020-01913-6.

何甜，陈缤彬，石清明，等.帕金森病相关分子机制研究进展［J］.局解手术学杂志，2022，31（5）：456-460.doi：10.11659/jjssx. 11E021034http://dx.doi.org/10.11659/jjssx.11E021034.

罗汉将，李佳昱，刘承伟，等.α-Syn过表达对帕金森病模型小鼠黑质多巴胺受体D1表达的影响［J］.中国神经免疫学和神经病学杂志，2021，28（1）：36-40.doi：10.3969/j.issn.1006-2963.2021. 01.006http://dx.doi.org/10.3969/j.issn.1006-2963.2021.01.006.

Hodara R， Norris EH， Giasson BI， et al.Functional consequences of alpha-synuclein tyrosine nitration：diminished binding to lipid vesicles and increased fibril formation［J］.J Biol Chem， 2004，279（46）：47746-47753.doi：10.1074/jbc.M408906200http://dx.doi.org/10.1074/jbc.M408906200.

Winslow AR， Chen CW， Corrochano S， et al.α-Synuclein impairs macroautophagy：implications for Parkinson's disease［J］.J Cell Biol，2010，190（6）：1023-1037.doi：10.1083/jcb.201003122http://dx.doi.org/10.1083/jcb.201003122.

Cuervo AM， Stefanis L， Fredenburg R，et al.Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy［J］.Science， 2004， 305（5688）：1292-1295.doi：10.1126/science. 1101738http://dx.doi.org/10.1126/science.1101738.

Mehra S，Sahay S，Maji SK.α-Synuclein misfolding and aggregation：Implications in Parkinson's disease pathogenesis［J］.Biochim Biophys Acta Proteins Proteom，2019，1867（10）：890-908.doi：10.1016/j.bbapap.2019.03.001http://dx.doi.org/10.1016/j.bbapap.2019.03.001.

Luk KC，Kehm V，Carroll J， et al.Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice［J］.Science，2012，338（6109）：949-953.doi：10.1126/science. 1227157http://dx.doi.org/10.1126/science.1227157.

Rey NL，Steiner JA，Maroof N， et al.Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease［J］.J Exp Med，2016，213（9）：1759-1778.doi：10.1084/jem.20160368http://dx.doi.org/10.1084/jem.20160368.

Rey NL，Petit GH，Bousset L， et al.Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice［J］.Acta Neuropathol，2013，126（4）：555-573.doi：10.1007/s00401-013-1160-3http://dx.doi.org/10.1007/s00401-013-1160-3.

Lee HJ， Bae EJ， Lee SJ.Extracellular α-synuclein-a novel and crucial factor in Lewy body diseases［J］.Nat Rev Neurol，2014，10（2）：92-98.doi：10.1038/nrneurol.2013.275http://dx.doi.org/10.1038/nrneurol.2013.275.

Svensson E，Horváth-Puhó E，Thomsen RW， et al.Vagotomy and subsequent risk of Parkinson's disease［J］.Ann Neurol，2015，78（4）：522-529.doi：10.1002/ana.24448http://dx.doi.org/10.1002/ana.24448.

Kim S，Kwon SH，Kam TI， et al.Transneuronal propagation of pathologic α-Synuclein from the gut to the brain models Parkinson's Disease［J］.Neuron，2019，103（4）：627-641.e7.doi：10.1016/j.neuron.2019.05.035http://dx.doi.org/10.1016/j.neuron.2019.05.035.

Rietdijk CD，Perez-Pardo P，Garssen J， et al.Exploring Braak's hypothesis of Parkinson's disease［J］.Front Neurol，2017，8：37.doi：10.3389/fneur.2017.00037http://dx.doi.org/10.3389/fneur.2017.00037.

Sampson TR， Debelius JW， Thron T， et al.Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease［J］.Cell，2016，167（6）：1469-1480.e12.doi：10.1016/j.cell.2016.11.018http://dx.doi.org/10.1016/j.cell.2016.11.018.

Sanders DW，Kaufman SK，Holmes BB， et al.Prions and protein assemblies that convey biological information in health and disease［J］.Neuron，2016，89（3）：433-448.doi：10.1016/j.neuron. 2016.01.026http://dx.doi.org/10.1016/j.neuron.2016.01.026.

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