Effect of reducing contrast agent dosage based on body surface area on the quality of liver enhanced dual-energy CT images

LEI Yu-zhu; LI Xiao-ming; JI Bing; WANG Jie; LI Jing; CHEN Wei; LI Lian

doi:10.11659/jjssx.11E023116

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Effect of reducing contrast agent dosage based on body surface area on the quality of liver enhanced dual-energy CT images

Clinical Research | 更新时间：2024-12-10

- Effect of reducing contrast agent dosage based on body surface area on the quality of liver enhanced dual-energy CT images
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 12, Pages: 1048-1051(2024)
- 作者机构：
  
  1.陆军第七十九集团军医院医学影像科，辽宁辽阳 111000
  2.陆军军医大学第一附属医院放射科，重庆 400038
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.11E023116
  CLC： R445.3
- Published：25 December 2024，
  
  Received：25 November 2023，
- 稿件说明：
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雷瑜竹,李晓明,季冰等.基于体表面积降低对比剂剂量对肝脏增强双能CT图像质量的影响[J].局解手术学杂志,2024,33(12):1048-1051.

LEI Yu-zhu,LI Xiao-ming,JI Bing,et al.Effect of reducing contrast agent dosage based on body surface area on the quality of liver enhanced dual-energy CT images[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(12):1048-1051.
雷瑜竹,李晓明,季冰等.基于体表面积降低对比剂剂量对肝脏增强双能CT图像质量的影响[J].局解手术学杂志,2024,33(12):1048-1051. DOI： 10.11659/jjssx.11E023116.

LEI Yu-zhu,LI Xiao-ming,JI Bing,et al.Effect of reducing contrast agent dosage based on body surface area on the quality of liver enhanced dual-energy CT images[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(12):1048-1051. DOI： 10.11659/jjssx.11E023116.

摘要

目的

基于体表面积（BSA）个性化计算对比剂剂量，探究能否在减少对比剂剂量的情况下，通过双能CT获得虚拟单能量或重建融合的方法达到不影响门静脉主干增强效果的可行性。

方法

选择陆军军医大学第一附属医院接受上腹部CT增强检查的60例患者，分为正常剂量组和降低剂量组。正常剂量组以BSA估算值作为对比剂剂量，降低剂量组采用BSA估算值减少20%作为对比剂剂量。2组患者门静脉期均采用双能CT扫描方式，且扫描参数相同。扫描结束后，用西门子多模图像工作站Syngo双能量后处理软件对降低剂量组门静脉期5 mm层厚图像进行“最佳对比度（OC）”和“单能量（Mono）”两种方式重建融合，测量各组图像中的门静脉主干和正常肝实质的CT值和SD值，计算岀门静脉与肝实质的对比噪声比（CNR）和门静脉信噪比（SNR）。

结果

与正常剂量组相比，降低剂量OC组主观评分差异无统计学意义（

0.05），但图像门静脉主干CNR、SNR显著提高（

0.05）。降低剂量Mono组图像门静脉CT值、门静脉与肝实质差值明显低于正常剂量组，且主观评分最低，差异均具有统计学意义（

0.05）。

结论

在降低20%对比剂剂量的情况下，通过双能CT重建融合的方法，不仅能减少对比剂对患者的损害，而且可显著改善病灶显示，提高肝脏增强图像质量一致性。

Abstract

Objective

Personalized calculation of contrast agent dose based on body surface area （BSA） was conducted to explore the feasibility of obtaining virtual single energy or reconstruction fusion through dual-energy CT without affecting the enhancement effect of portal vein trunk under the condition of reducing the contrast agent dose.

Methods

A total of 60 patients who received enhanced upper abdominal CT examination in the First Affiliated Hospital of Army Medical University were selected and divided into the normal dose group and the reduced dose group. The normal dose group used the BSA estimated value as the contrast agent dose，and the reduced dose group used the BSA estimated value reduced by 20% as the contrast agent dose. Both groups of patients were treated with dual-energy CT scanning in portal vein stage，and the scanning parameters were the same. After scanning，Syngo dual-energy post-processing software of Siemens multi-mode image workstation was used to reconstruct and fuse the 5 mm layer thickness image of the portal vein stage in the reduced dose group by two methods："optimum contrast（OC）" and "monoenergetic（Mono）". The CT value and SD value of the portal vein trunk and the normal liver parenchyma of images in each group were measured. The contrast to noise ratio （CNR） of theportal vein and the liver parenchyma and portal vein signal to ratio （SNR）were calculated.

Results

Compared with the normal dose group， there was no

statistically significant difference in the subjective score in the reduced dose OC group （

0.05）， but the CNR and SNR of the portal vein trunk in the images were significantly improved （

0.05）.The portal vein CT value and the difference between portal vein and liver parenchyma in the reduced dose Mono group were significantly lower than those in the normal dose group，and the subjective score was the lowest， with statistical differences （

0.05）.

Conclusion

In the case of reducing the contrast agent dose by 20%，the dual-energy CT reconstruction fusion method can not only reduce the damage of contrast agent to patients，but also significantly improve the lesion display，and improve the consistency of liver enhancement image quality.

关键词

双能CT肝脏增强对比剂体表面积

Keywords

dual-energy CTliver enhancementcontrast agentbody surface area

references

周彦宇，林雁玲.双源CT虚拟单能量成像技术不同keV值对门静脉成像质量提高的研究［J］.现代医用影像学，2022，31（2）：199-203.doi：10.3969/j.issn.1006-7035.2022.2.xdyyyxx202202001http://dx.doi.org/10.3969/j.issn.1006-7035.2022.2.xdyyyxx202202001.

吴晶晶，吴丽霞，舒毅，等.320能谱CT技术对门静脉图像质量及辐射剂量影响的初步研究［J］.实用放射学杂志，2022，38（3）：483-486.doi：10.3969/j.issn.1002-1671.2022.03.032http://dx.doi.org/10.3969/j.issn.1002-1671.2022.03.032.

王世伟，李金锋，邹颖，等.双层探测器能谱CT单能级成像对门静脉成像质量的影响［J］.中国临床医学影像杂志，2020，31（6）：425-428.doi：10.12117/jccmi.2020.06.012http://dx.doi.org/10.12117/jccmi.2020.06.012.

Amato E，Salamone I，Naso S，et al.Can contrast media increase organ doses in CT examinations？A clinical study［J］.Ajr Am J Roentgenol，2013，200（6）：1288-1293.doi：10.2214/AJR.12.8958http://dx.doi.org/10.2214/AJR.12.8958.

杨克柽，李莲，王建杰，等.肝脏CT门静脉成像中对比剂剂量的估算方法［J］.临床放射学杂志，2016，35（4）：630-633.doi：10.13437/j.cnki.jcr.2016.04.036http://dx.doi.org/10.13437/j.cnki.jcr.2016.04.036.

Kondo H，Kanematsu M，Goshima S，et al.Body size indices to determine iodine mass with contrast-enhanced multi-detector computed tomography of the upper abdomen： does body surface area outperform total body weight or lean body weight？［J］.Eur Radiol，2013，23（7）：1855-1861.doi：10.1007/s00330-013-2808-zhttp://dx.doi.org/10.1007/s00330-013-2808-z.

胡斌，陈静静，徐文坚，等.双能CT改进的虚拟单能成像重建算法的门静脉图像质量评估［J］.首都医科大学学报，2019，40（6）：943-947.doi：10.3969/j.issn.1006-7795.2019.06.023http://dx.doi.org/10.3969/j.issn.1006-7795.2019.06.023.

李莲.肝脏门静脉期双能CT：单能量图像与融合图像的比较［J］.中国医学计算机成像杂志，2017，23（2）：140-145.doi：10.3969/j.issn.1006-5741.2017.02.008http://dx.doi.org/10.3969/j.issn.1006-5741.2017.02.008.

Tsutomu K，Noriyuki K，Hirofumi M，et al.Standardization of the body

surface area （BSA） formula to calculate the dose of anticancer agents in

Japan［J］.Jpn J Clin Oncol，2003（6）：309-313.doi：10.1093/jjco/hyg062http://dx.doi.org/10.1093/jjco/hyg062.

钟志明，潘慧，班统幸，等.新型非对比剂增强MR血管成像技术用于肝门静脉成像的可行性研究［J］.影像科学与光化学，2024，42（1）：16-22.doi：10.7517/issn.1674-0475.231013http://dx.doi.org/10.7517/issn.1674-0475.231013.

王琦，刘响，王丽佳，等.双能CT非线性融合技术提高门静脉血管图像质量［J］.中国医学影像学杂志，2014，22（6）：427-430.doi：10.3969/j.issn.1005-5185.2014.06.009http://dx.doi.org/10.3969/j.issn.1005-5185.2014.06.009.

陈瑜，秦艳，曾清.对比剂肾病的防治进展［J］.中国当代医药，2022，29（8）：33-36.doi：10.3969/j.issn.1674-4721.2022. 08.009http://dx.doi.org/10.3969/j.issn.1674-4721.2022.08.009.

段鹏，张小勇，张赛丹.大剂量阿托伐他汀序贯治疗对急性非ST段抬高型心肌梗死患者围手术期对比剂肾病的影响［J］.中国动脉硬化杂志，2016，24（7）：711-714.doi：1007-3949（2016）24-07-0711-04http://dx.doi.org/1007-3949（2016）24-07-0711-04.

Choi JY，Kim MH，Kim S，et al.Effectiveness evaluation about the volume reduction of contrast media and radiation dose with 100 kVp in abdomen-pelvis CT［J］.J Korean Soc Comput Tomogr Technol，2019，21（2）：doi：10.31320/JKSCT.2019.21.2.41.

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