Correlation study between peripheral blood NLR, hs-CRP/ALB, HMGB1 and nosocomial infection after pediatric laparoscopic intussusception reduction

GAO Lei; LIU Wei-dong; QI Yan-wei; WANG Ping

doi:10.11659/jjssx.11E022170

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Correlation study between peripheral blood NLR, hs-CRP/ALB, HMGB1 and nosocomial infection after pediatric laparoscopic intussusception reduction

Clinical Research | 更新时间：2023-10-23

- Correlation study between peripheral blood NLR, hs-CRP/ALB, HMGB1 and nosocomial infection after pediatric laparoscopic intussusception reduction
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 10, Pages: 886-889(2023)
- 作者机构：
  
  河北省儿童医院普外科，河北石家庄 050031
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.11E022170
  CLC： R619+.3
- Published：25 October 2023，
  
  Received：29 November 2022，
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高磊,刘伟栋,祁艳卫等.外周血NLR、hs-CRP/ALB、HMGB1与小儿腹腔镜下肠套叠复位术后医院感染的相关性研究[J].局解手术学杂志,2023,32(10):886-889.

GAO Lei,LIU Wei-dong,QI Yan-wei,et al.Correlation study between peripheral blood NLR, hs-CRP/ALB, HMGB1 and nosocomial infection after pediatric laparoscopic intussusception reduction[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(10):886-889.
高磊,刘伟栋,祁艳卫等.外周血NLR、hs-CRP/ALB、HMGB1与小儿腹腔镜下肠套叠复位术后医院感染的相关性研究[J].局解手术学杂志,2023,32(10):886-889. DOI： 10.11659/jjssx.11E022170.

GAO Lei,LIU Wei-dong,QI Yan-wei,et al.Correlation study between peripheral blood NLR, hs-CRP/ALB, HMGB1 and nosocomial infection after pediatric laparoscopic intussusception reduction[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(10):886-889. DOI： 10.11659/jjssx.11E022170.

摘要

目的

探讨外周血中性粒细胞与淋巴细胞比值（NLR）、超敏C反应蛋白/白蛋白（hs-CRP/ALB）、高迁移率族蛋白B1（HMGB1）对小儿腹腔镜下肠套叠复位术后医院感染的预测价值。

方法

收集我院接受小儿腹腔镜下肠套叠复位术的104例患儿的临床资料，根据术后是否发生医院感染将其分为未感染组和感染组，再根据感染程度将感染组患儿分为轻度组和中重度组。采用全自动血细胞分析仪检测中性粒细胞及淋巴细胞，计算NLR。采用ELISA法检测hs-CRP、ALB、HMGB1水平，并计算hs-CRP/ALB。采用受试者工作特征（

ROC

）曲线分析外周血NLR、hs-CRP/ALB、HMGB1水平对小儿腹腔镜下肠套叠复位术后医院感染的预测价值；多因素

Logistic

回归分析小儿腹腔镜下肠套叠复位术后医院感染的影响因素。

结果

与未感染组相比，感染组外周血NLR、hs-CRP/ALB、HMGB1水平及手术时间≥2 h患儿比例较高（

0.05）。NLR、hs-CRP/ALB、HMGB1及三者联合预测小儿腹腔镜下肠套叠复位术后医院感染的曲线下面积（

AUC

）分别为0.812、0.785、0.724、0.922，特异性分别为88.6%、85.7%、57.1%、78.6%，敏感度分别为61.8%、61.8%、79.4%、91.2%。NLR、hs-CRP/ALB、HMGB1升高均为小儿腹腔镜下肠套叠复位术后医院感染的独立危险因素（

0.05）。与轻度组相比，中重度组肠套叠患儿外周血NLR、hs-CRP/ALB、HMGB1水平较高（

0.05）。

结论

外周血NLR、hs-CRP/ALB、HMGB1水平异常升高与小儿腹腔镜下肠套叠复位术后医院感染密切相关，可作为预测术后感染、评估感染程度的重要指标。

Abstract

Objective

To investigate the predictive value of peripheral blood neutrophil-to-lymphocyte ratio （NLR）， high sensitivity C-reactive protein/albumin （hs-CRP/ALB）， and high mobility group protein B1 （HMGB1） on nosocomial infection after pediatric laparoscopic intussusception reduction.

Methods

The clinical data of 104 children who received pediatric laparoscopic intussusception reduction in our hospital were collected， the patients were divided into the uninfected group and infection group according to the occurrence of nosocomial infection after operation， and the children in the infection group were divided into the mild group and moderate-severe group according to their infection degree.The neutrophils and lymphocytes were detected by the automatic blood cell analyzer， and NLR was calculated.The levels of hs-CRP， ALB， and HMGB1 were detected by ELISA，and hs-CRP/ALB was calculated.The

receiver operating characteristic

（

ROC

） curve was used to analyze the predictive value of peripheral blood NLR， hs-CRP/ALB and HMGB1 levels for nosocomial infection after pediatric laparoscopic intussusception reduction.The influencing factors of nosocomial infection after pediatric laparoscopic intussusception reduction were analyzed by multivariate

Logistic

regression.

Results

Compared with the uninfected group， the peripheral blood NLR， hs-CRP/ALB， HMGB1 levels and the proportion of children with operation time ≥ 2 hours in the infected group were higher （

0.05）.The

area under the curve

（

AUC

） of NLR， hs-CRP/ALB， HMGB1 and their combination in predicting nosocomial infection after pediatric laparoscopic intussusception reduction were 0.812， 0.785， 0.724， and 0.922， respectively， with specificities of 88.6%， 85.7%， 57.1%， and 78.6%， respectively， and the sensitivities of 61.8%， 61.8%， 79.4%， and 91.2%， respectively.The increases of NLR， hs-CRP/ALB and HMGB1 were all the independent risk factors for nosocomial infection after pediatric laparoscopic intussusception reduction （

0.05）.Compared with the mild group， the peripheral blood NLR， hs-CRP/ALB and HMGB1 levels of the children with intussusception in the moderate-severe group were higher （

0.05）.

Conclusion

The abnormal increases of NLR， hs-CRP/ALB and HMGB1 levels in peripheral blood are closely related to nosocomial infection after pediatric laparoscopic intussusception reduction， which can be used as the important indicators for predicting postoperative infection and evaluating the infection degree.

关键词

儿童腹腔镜下肠套叠复位术医院感染中性粒细胞与淋巴细胞比值超敏C反应蛋白/白蛋白高迁移率族蛋白B1

Keywords

childrenlaparoscopic intussusception reductionnosocomial infectionneutrophil to lymphocyte ratiohigh sensitivity C-reactive protein/albuminhigh mobility group protein B1

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