Clinical study of laparoscopic surgery combined with anti-infection and dienogest in the treatment of endometriosis

ZHANG Sen; CHANG Ru; GUO Chao

doi:10.11659/jjssx.11E022145

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Clinical study of laparoscopic surgery combined with anti-infection and dienogest in the treatment of endometriosis

Clinical Research | 更新时间：2023-07-31

- Clinical study of laparoscopic surgery combined with anti-infection and dienogest in the treatment of endometriosis
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 8, Pages: 708-711(2023)
- 作者机构：
  
  衡水市人民医院手术室，河北衡水 053000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.11E022145
  CLC： R713.4
- Published：25 August 2023，
  
  Received：27 November 2022，
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张森,常茹,郭超.腹腔镜手术联合抗感染及地诺孕素治疗子宫内膜异位症的临床研究[J].局解手术学杂志,2023,32(08):708-711.

.Clinical study of laparoscopic surgery combined with anti-infection and dienogest in the treatment of endometriosis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(08):708-711.
张森,常茹,郭超.腹腔镜手术联合抗感染及地诺孕素治疗子宫内膜异位症的临床研究[J].局解手术学杂志,2023,32(08):708-711. DOI： 10.11659/jjssx.11E022145.

.Clinical study of laparoscopic surgery combined with anti-infection and dienogest in the treatment of endometriosis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(08):708-711. DOI： 10.11659/jjssx.11E022145.

摘要

目的

探析腹腔镜手术联合术后抗感染及地诺孕素三联策略在子宫内膜异位症（EMs）中的应用效果。

方法

选择于本院就诊的90例EMs患者，采用随机数表法分为观察组和对照组，每组45例。2组均使用腹腔镜手术联合术后抗感染治疗策略，观察组在此基础上联合地诺孕素持续治疗3个月。对比2组症状改善率、手术前后子宫内膜异位症生育指数（EFI）、细胞因子[高迁移率族蛋白1（HMGB1）、纤维蛋白原(FIB)、转化生长因子β1（TNF-β1）]表达水平、输卵管通畅率、妊娠率、复发率、不良反应发生率。

结果

观察组症状改善率高于对照组（

0.05）。观察组术后EFI高于对照组（

0.05），HMGB1、FIB、TNF-β1水平低于对照组（

0.05）。观察组术后输卵管通畅率、妊娠率高于对照组（

0.05），复发率低于对照组（

0.05）；2组不良反应发生率比较差异无统计学意义（

0.05）。

结论

基于腹腔镜手术联合术后抗感染及地诺孕素的三联策略治疗EMs的临床效果显著，可有效提高EFI、输卵管通畅率、妊娠率，纠正HMGB1、FIB、TNF-β1等细胞因子水平，降低复发率，安全性较高。

Abstract

Objective

To explore the efficacy of laparoscopic surgery combined with postoperative anti-infection and dienogest in endometriosis （EMs）.

Methods

A total of 90 patients with EMs were selected and divided into the observation group and the control group by random number table method， with 45 cases in each group.Both groups were treated with laparoscopic surgery combined with postoperative anti-infective treatment strategy， and the observation group continued to treat with dienogest for 3 months.The symptom improvement rates， endometriosis fertility index （EFI） before and after surgery， expression levels of cytokine ［high mobility groupbox-1 （HMGB1）， fibrinogen （FIB）， and transforming growth factor beta 1 （TNF-β1）］， tubal patency rate， pregnancy rate， recurrence rate， and incidence of adverse reactions.

Results

The symptom improvement rate of the observation group was higher than that of the control group （

0.05）.The EFI after surgery of the observation group was higher than that of the control group （

0.05），the levels of HMGB1， FIB， TNF-β1 were lower than those in the control group （

0.05）.The tubal patency rate and pregnancy rate after surgery of the observation group were higher than those of the control group（

0.05）， and the recurrence rate was lower than that of the control group （

0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （

0.05）.

Conclusion

The triple strategy of laparoscopic surgery combined with postoperative anti-infection and dienogest has significant clinical effect in the treatment of EMs， which can effectively improve the EFI， tubal patency rate， and pregnancy rate， and correct the levels of cytokines such as HMGB1， FIB， TNF-β1， and reduce the recurrence rate， with high safety.

关键词

腹腔镜手术抗感染地诺孕素子宫内膜异位症输卵管通畅率妊娠率

Keywords

laparoscopic surgeryanti-infectiondienogestendometriosistubal patency ratepregnancy rate

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