Research progress of long non-coding RNAs in the regulation of intervertebral disc degeneration
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 6, Pages: 547-554(2023)
- 作者机构：
1.内蒙古医科大学研究生学院，内蒙古 呼和浩特 010030
2.内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
3.内蒙古医科大学附属人民医院骨科，内蒙古 呼和浩特 010020
- 作者简介：
- 基金信息：
DOI：10.11659/jjssx.11E022143
CLC： R681.53Published：25 June 2023，
Received：26 November 2022，
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何志伟,郭佳霖,李志军等.长链非编码RNA调控椎间盘退变的研究进展[J].局解手术学杂志,2023,32(06):547-554.
HE Zhi-wei,GUO Jia-lin,LI Zhi-jun,et al.Research progress of long non-coding RNAs in the regulation of intervertebral disc degeneration[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(06):547-554.
何志伟,郭佳霖,李志军等.长链非编码RNA调控椎间盘退变的研究进展[J].局解手术学杂志,2023,32(06):547-554. DOI： 10.11659/jjssx.11E022143.
HE Zhi-wei,GUO Jia-lin,LI Zhi-jun,et al.Research progress of long non-coding RNAs in the regulation of intervertebral disc degeneration[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(06):547-554. DOI： 10.11659/jjssx.11E022143.
摘要
椎间盘退变(IDD)是导致腰痛的主要原因
目前在细胞和分子水平寻找IDD的机制得到了较多关注。已有研究报道长链非编码RNA（lncRNA）影响IDD的病理过程。本文综述了lncRNA对髓核细胞增殖、凋亡、衰老、自噬等方面的调控，总结了调控椎间盘内细胞增殖、凋亡和ECM合成与降解的lncRNA及相关靶基因或通路。值得注意的是，有的lncRNA不充当竞争内源性RNA（ceRNA），而是直接结合稳定相关微小RNA(miRNA)，增强其miRNA表达从而调控IDD。此外，目前的研究主要报道的是lncRNA对椎间盘内髓核的调控，未来可进一步探究lncRNA对软骨终板和纤维环的调控，为lncRNA调控IDD提供更多的理论支持和依据。
Abstract
Intervertebral disc degeneration （IDD） is the main cause of low back pain. At present， more attention has been paid to finding the mechanism of IDD at the cellular and molecular levels. It has been reported that long non-coding RNAs （lncRNAs） affects the pathological process of IDD. This article reviews the regulation of lncRNAs on the proliferation， apoptosis， senescence and autophagy and other aspects of nucleus pulposus cells， and summarizes the lncRNAs and related target genes or pathways that regulate the proliferation， apoptosis， ECM synthesis and degradation of cells in the intervertebral disc. It is worth noting that some lncRNAs do not act as competing endogenous RNAs （ceRNAs），but directly bind to stable related microRNAs（miRNAs） and enhance their miRNAs expression to regulate IDD.In addition，current studies mainly report the regulation of lncRNAs on nucleus pulposus in the intervertebral disc.In the future， further exploration of the regulation of lncRNAs on the cartilage endplate and annulus fibrosus can provide more theoretical support and basis for lncRNAs regulating IDD.
关键词
lncRNA椎间盘退变增殖氧化应激凋亡衰老细胞外基质
Keywords
lncRNAintervertebral disc degenerationproliferationoxidative stressapoptosissenescenceextracellular matrix
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