Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery

SONG Chun-guang; NIU Zhi-xin; HE Feng; XU Xi-ming; YUE Chun-hua

doi:10.11659/jjssx.10E023038

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Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery

Gastroenterology and Hepatobiliology | 更新时间：2024-10-22

- Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 10, Pages: 863-866(2024)
- 作者机构：
  
  1.秦皇岛市第一医院肛肠外科，河北秦皇岛 066000
  2.秦皇岛市第一医院麻醉科，河北秦皇岛 066000
  3.秦皇岛市第一医院质量管理处，河北秦皇岛 066000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.10E023038
  CLC： R735.3
- Published：25 October 2024，
  
  Received：10 October 2023，
- 稿件说明：
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宋春光,牛志新,何峰等.结肠癌组织TLR4、CHI3L1表达与根治术后预后的关系[J].局解手术学杂志,2024,33(10):863-866.

SONG Chun-guang,NIU Zhi-xin,HE Feng,et al.Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):863-866.
宋春光,牛志新,何峰等.结肠癌组织TLR4、CHI3L1表达与根治术后预后的关系[J].局解手术学杂志,2024,33(10):863-866. DOI： 10.11659/jjssx.10E023038.

SONG Chun-guang,NIU Zhi-xin,HE Feng,et al.Correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis after radical surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):863-866. DOI： 10.11659/jjssx.10E023038.

摘要

目的

探讨结肠癌组织中Toll样受体4（TLR4）、壳多糖酶3样蛋白1（CHI3L1）的表达及其与患者根治术后预后的关系。

方法

选取2017年1月至2018年5月于我院行结肠癌根治术的152例患者为研究对象，根据患者术后5年生存情况分为预后良好组（

=97）和预后不良组（

=47）。采用免疫组织化学染色法检测结肠癌组织及癌旁组织中TLR4、CHI3L1的表达水平；分析结肠癌组织中TLR4和CHI3L1表达与患者预后的关系，并分析结肠癌患者预后的影响因素。

结果

结肠癌组织中TLR4和CHI3L1阳性表达率显著高于癌旁组织（

0.05）。结肠癌组织中TLR4表达与患者肿瘤分化程度、临床分期和淋巴结转移有关（

0.05），CHI3L1表达与结肠癌患者肿瘤直径、肿瘤分化程度、临床分期和淋巴结转移有关（

0.05）。与预后良好组比较，预后不良组患者肿瘤低分化、临床分期Ⅲ期、淋巴结转移、TLR4阳性表达和CHI3L1阳性表达的占比较高（

0.05）。TLR4阳性表达患者5年生存率为60.38%，低于TLR4阴性表达患者的86.84%（

=9.104，

0.05）；CHI3L1阳性表达患者5年生存率为58.06%，低于CHI3L1阴性表达患者的84.31%（

=10.935，

0.05）。TLR4阳性、CHI3L1阳性、肿瘤低分化、临床分期Ⅲ期、淋巴结转移是结肠癌患者预后的独立危险因素（

0.05）。

结论

TLR4和CHI3L1与结肠癌的发生和临床病理特征有关，且结肠癌组织中TLR4和CHI3L1阳性表达不利于患者预后，二者有望成为临床治疗靶点。

Abstract

Objective

To investigate the correlation between the expression of Toll-like receptor 4 （TLR4） and chitosanase 3-like protein 1 （CHI3L1） in colon cancer tissue and the prognosis of patients after radical surgery.

Methods

A total of 152 patients who underwent radical colon cancer surgery in our hospital from January 2017 to May 2018 were collected and divided into the good prognosis group （

=97） and the poor prognosis group （

=47） according to the 5-year survival status after surgery. Immunohistochemical staining was applied to detect the expression levels of TLR4 and CHI3L1 in colon cancer tissues and adjacent tissues； the correlation between the expression of TLR4 and CHI3L1 in colon cancer tissue and the prognosis of patients was analyzed，and the influencing factors for prognosis of colon cancer patients were analyzed.

Results

The positive expression rates of TLR4 and CHI3L1 in colon cancer tissues were obviously higher than those in adjacent tissues （

0.05）. The expression of TLR4 in colon cancer tissue was related to the degree of tumor differentiation，clinical staging，and lymph node metastasis of colon cancer patients （

0.05），the expression of CHI3L1 was related to the tumor diameter，degree of tumor differentiation，clin

ical staging，and lymph node metastasis of colon cancer patients （

0.05）. Compared with the good prognosis group，the poor prognosis group had higher proportions of patients with poorly differentiated tumor，clinical stageⅢ，lymph node metastasis，and positive expression of TLR4 and CHI3L1 （

0.05）. The 5-year survival rate of patient with TLR4 positive expression was 60.38%，which was lower than that of 86.84% of patients with TLR4 negative expression （

=9.104，

0.05）； the 5-year survival rate of patients with CHI3L1 positive expression was 58.06%，which was lower than that of 84.31% of patients with CHI3L1 negative expression （

=10.935，

0.05）. The positive expression of TLR4 and CHI3L1，poorly differentiated tumor，clinical stage Ⅲ，and lymph node metastasis were the independent risk factors for the prognosis of colon cancer patients （

0.05）.

Conclusion

TLR4 and CHI3L1 are related to the occurrence and clinicopathological features of colon cancer，and the positive expression of TLR4 and CHI3L1 in colon cancer tissues is not conducive to the prognosis of patients，so both of them are expected to become clinical treatment targets.

关键词

结肠癌根治术预后Toll样受体4壳多糖酶3样蛋白1

Keywords

colon cancerradical surgeryprognosisToll-like receptor 4chitinase 3-like protein 1

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