Research progress on metabolic disorder of skeletal muscle in patients with polycystic ovary syndrome

GUO Xiao-xiao; PANG Yi-wei; TIAN Hong-cheng; WANG Yan-lin; HAN Lei

doi:10.11659/jjssx.10E022135

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Research progress on metabolic disorder of skeletal muscle in patients with polycystic ovary syndrome

Review | 更新时间：2023-07-17

- Research progress on metabolic disorder of skeletal muscle in patients with polycystic ovary syndrome
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 7, Pages: 645-648(2023)
- 作者机构：
  
  1.滨州医学院附属医院生殖医学科，山东滨州 256603
  2.遵义医科大学附属妇幼保健院生殖医学科，贵州遵义 563000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.10E022135
  CLC： R711.75
- Published：25 July 2023，
  
  Received：26 October 2022，
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郭晓晓,庞益伟,田洪成等.多囊卵巢综合征骨骼肌代谢障碍的研究进展[J].局解手术学杂志,2023,32(07):645-648.

GUO Xiao-xiao,PANG Yi-wei,TIAN Hong-cheng,et al.Research progress on metabolic disorder of skeletal muscle in patients with polycystic ovary syndrome[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(07):645-648.
郭晓晓,庞益伟,田洪成等.多囊卵巢综合征骨骼肌代谢障碍的研究进展[J].局解手术学杂志,2023,32(07):645-648. DOI： 10.11659/jjssx.10E022135.

GUO Xiao-xiao,PANG Yi-wei,TIAN Hong-cheng,et al.Research progress on metabolic disorder of skeletal muscle in patients with polycystic ovary syndrome[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(07):645-648. DOI： 10.11659/jjssx.10E022135.

摘要

多囊卵巢综合征（PCOS）是影响女性健康最常见的生殖内分泌疾病之一，也是辅助生殖助孕的一项重要指征。大量研究证实PCOS患者发生胰岛素抵抗（IR）、2型糖尿病、非酒精性脂肪肝和心血管疾病的风险显著升高，因此PCOS已成为影响患者终身健康的代谢性疾病。尽管IR并非PCOS的诊断标准，但PCOS患者中IR普遍存在且病理生理特征明显。雄激素在IR发生过程中具有双向调节效应，两者之间存在复杂的相互作用。骨骼肌是雄激素作用的靶器官，在维持代谢稳态中发挥关键作用，也是胰岛素介导葡萄糖利用的主要场所。近年来，骨骼肌代谢功能障碍在PCOS发病中的作用逐渐成为学界关注的焦点。分析PCOS女性骨骼肌代谢功能障碍的特征及可能的分子机制，或将为改善PCOS患者的代谢功能提供新的治疗思路。

Abstract

Polycystic ovary syndrome （PCOS） is one of the most common reproductive endocrine diseases affecting women's health. It is also an important indication of assisted reproduction and pregnancy. A large number of studies have confirmed that PCOS patients have a significantly increased risk of insulin resistance （IR），type 2 diabetes mellitus，non-alcoholic fatty liver disease and cardiovascular disease，therefore PCOS has been a metabolic disease that affects the lifelong health of patients. Although IR is not a diagnostic criterion for PCOS，IR is common and has obvious pathophysiological characteristics in PCOS patients. Androgens have bidirectional regulatory effects in the process of IR development，and there is a complex interaction between them. Skeletal muscle is the target organ of androgen action，which plays a key role in maintaining metabolic homeostasis，and is also the main site where insulin mediates glucose utilization. In recent years， the role of skeletal muscle metabolic dysfunction in the pathogenesis of PCOS has gradually become the focus of academic attention. Analyzing the characteristics and possible molecular mechanisms of skeletal muscle metabolic dysfunction in women with PCOS，may provide new therapeutic ideas for improving the metabolic function of PCOS patients.

关键词

高雄激素胰岛素抵抗多囊卵巢综合征骨骼肌代谢障碍

Keywords

androgen excessinsulin resistancepolycystic ovary syndromeskeletal musclemetabolic disorder

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