Effect of subanesthetic dose of esketamine on postoperative recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer

YANG Chang-jian; HAN Li; ZHAO Yue; YUAN Chen; YANG Fen; XIE Yang; SHEN Jun

doi:10.11659/jjssx.09E023010

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Effect of subanesthetic dose of esketamine on postoperative recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer

Clinical Research | 更新时间：2024-09-29

- Effect of subanesthetic dose of esketamine on postoperative recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 9, Pages: 820-824(2024)
- 作者机构：
  
  1.南京医科大学附属苏州医院/苏州市立医院麻醉科/南京医科大学姑苏学院，江苏苏州 215002
  2.南京医科大学附属苏州医院/苏州市立医院骨外科/南京医科大学姑苏学院，江苏苏州 215002
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.09E023010
  CLC： R735.34;R614
- Published：25 September 2024，
  
  Received：04 September 2023，
- 稿件说明：
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杨昌建,韩丽,赵月等.亚麻醉剂量艾司氯胺酮对老年腹腔镜直肠癌根治术后康复的影响[J].局解手术学杂志,2024,33(09):820-824.

YANG Chang-jian,HAN Li,ZHAO Yue,et al.Effect of subanesthetic dose of esketamine on postoperative recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(09):820-824.
杨昌建,韩丽,赵月等.亚麻醉剂量艾司氯胺酮对老年腹腔镜直肠癌根治术后康复的影响[J].局解手术学杂志,2024,33(09):820-824. DOI： 10.11659/jjssx.09E023010.

YANG Chang-jian,HAN Li,ZHAO Yue,et al.Effect of subanesthetic dose of esketamine on postoperative recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(09):820-824. DOI： 10.11659/jjssx.09E023010.

摘要

目的

探讨亚麻醉剂量艾司氯胺酮用于术后镇痛对老年腹腔镜直肠癌根治术患者早期康复的影响。

方法

纳入拟行腹腔镜直肠癌根治术的老年患者，采用随机数字表法将患者分为AS组（61例，采用艾司氯胺酮静脉自控镇痛）和SF组（60例，采用舒芬太尼静脉自控镇痛）。比较2组患者手术时间、术中输液量、尿量、术中出血量、术后补救镇痛、术后48 h内患者静脉自控镇痛（PCIA）按压次数和曲马多用量、术后视觉模拟量表（VAS）评分、术后Ramsay镇静评分、术后首次下床活动时间、术后首次排气时间及术后首次进食时间。记录2组患者不良反应发生情况。术毕即刻、术后24 h和72 h采用ELISA法检测2组患者白细胞介素-6（IL-6）和C反应蛋白（CRP）水平。比较2组患者术后3 d、1周和1个月焦虑、抑郁评分。

结果

2组患者手术时间、术中输液量、尿量、术中出血量、术后补救镇痛、术后48 h内曲马多用量及术后48 h内PCIA按压次数比较，差异均无统计学意义（

0.05）。2组患者术毕即刻、术后24 h和72 h IL-6、CRP水平逐渐升高（

0.05），且AS组患者术后24 h和72 h的IL-6、CRP水平均显著低于SF组（

0.05）。AS组患者术后首次下床活动时间、术后首次排气时间、术后首次进食时间均早于SF组（

0.05）。AS组患者恶心、呕吐和头晕发生率显著低于SF组（

0.05）。AS组患者术后24 h和72 h的IL-6和CRP水平均显著低于SF组（

0.05）。AS组患者术后3 d和术后1周的焦虑和抑郁评分显著低于SF组（

0.05）。

结论

亚麻醉剂量艾司氯胺酮用于术后镇痛可减轻老年腹腔镜直肠癌根治术患者术后短期焦虑和抑郁，缓解术后疼痛和炎症反应，不良反应发生率低，有助于患者早期康复。

Abstract

Objective

To investigate the effect of subanesthetic dose of esketamine for postoperative analgesia on early recovery in elderly patients undergoing laparoscopic radical resection of rectal cancer.

Methods

Elderly patients undergoing laparoscopic radical resection of rectal cancer were included， and they were divided into the AS group （61 cases received esketamine for intravenous self-controlled analgesia） and the SF group （60 cases received sufentanil for intravenous self-controlled analgesia） by random number table method.The operation time， intraoperative infusion volume， urine output， intraoperative blood loss， postoperative rescue analgesia， tramadol dosage and the number of patient controlled intravenous analgesia （PCIA） compressions within 48 hours after surgery， postoperative visual analogue scale （VAS） score， Ramsay sedation score， first ambulation time after surgery， first gas passage time after surgery， and first feeding time after surgery were compared between the two groups. The occurrence of adverse reactions in the two groups was recorded. The levels of interleukin-6 （IL-6） and C-reactive protein （CRP） immediately after surgery， 24 hours and 72 hours after surgery in the two groups were detected by ELISA. The scores of anxiety and depression 3 days， 1 week and 1 month after surgery were compared between the two groups.

Results

There was no significant difference in the operation time， intraoperative infusion volume， urine output， intraoperative blood loss， postoperative rescue analgesia， tramadol dosage or PCIA compressions within 48 hours after surgery between the two groups （

0.05）.The levels of IL-6 and CRP gradually increased immediately after surgery and 24 hours and 72 hours after surgery in the two groups （

0.05）， and the levels of IL-6 and CRP 24 hours and 72 hours after surgery in the AS group were significantly lower than those in the SF group （

0.05）. The first ambulation time after surgery， first gas passage time after surgery， and first feeding time after surgery in the AS group were earlier than those in the SF group （

0.05）. The incidences of nausea， vomiting and dizziness in the AS group were significantly lower than those in the SF group （

0.05）. The levels of IL-6 and CRP 24 hours and 72 hours after surgery in the AS group were significantly lower than those in the SF group （

0.05）. The scores of anxiety and depression 3 days and 1 week after surgery in the AS group were significantly lower than those in the SF group （

0.05）.

Conclusion

Subanesthetic dose of esketamine for postoperative analgesia can alleviate short-term postoperative anxiety and depression in elderly patients undergoing laparoscopic radical resection of rectal cancer， relieve postoperative pain and inflammatory responses and have a low incidence of adverse reactions， which contribute to early recovery of patients.

关键词

亚麻醉剂量艾司氯胺酮老年患者腹腔镜直肠癌根治术术后镇痛早期康复

Keywords

subanesthetic doseesketamineelderly patientslaparoscopic radical resection of rectal cancerpostoperative analgesiaearly recovery

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