Research progress on molecular typing of endometrial cancer

SU Yuan-hua; XIAO Yan-bing

doi:10.11659/jjssx.08E023049

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Research progress on molecular typing of endometrial cancer

Review | 更新时间：2024-11-18

- Research progress on molecular typing of endometrial cancer
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 11, Pages: 1018-1022(2024)
- 作者机构：
  
  1.遵义医科大学研究生院，贵州遵义563000
  2.遵义医科大学附属妇幼保健院妇科，贵州遵义 563000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.08E023049
  CLC： R737.33
- Published：25 November 2024，
  
  Received：12 August 2023，
- 稿件说明：
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苏远华,肖雁冰.子宫内膜癌分子分型的研究进展[J].局解手术学杂志,2024,33(11):1018-1022.

SU Yuan-hua,XIAO Yan-bing.Research progress on molecular typing of endometrial cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(11):1018-1022.
苏远华,肖雁冰.子宫内膜癌分子分型的研究进展[J].局解手术学杂志,2024,33(11):1018-1022. DOI： 10.11659/jjssx.08E023049.

SU Yuan-hua,XIAO Yan-bing.Research progress on molecular typing of endometrial cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(11):1018-1022. DOI： 10.11659/jjssx.08E023049.

摘要

子宫内膜癌（EC）为女性常见的盆腔恶性子宫肿瘤，其传统分类方法主要是按照组织病理学形态来分型，但这种分类方法具有较高的个人主观性、较低的重复性，且评估预后的价值有限。随着癌症分子机制的研究和基因测序技术的发展，现能够通过研究癌症基因组图谱（TCGA）来重新分类。这种新的分类方法可以帮助医生对EC患者进行更精准的风险评估，为其提供更有效的个性化治疗方案，还能利用TCGA数据预测EC患者的预后情况，有望改善EC患者的治疗结果和生存率。本文总结了国内外关于分子分型在EC中的相关研究进展，以期为临床上EC的诊治提供新的指导和思路。

Abstract

Endometrial cancer （EC） is a common pelvic malignant uterine tumor in women. The traditional classification method of EC is mainly based on histopathological morphology，while this classification method has high personal subjectivity，low repeatability，and limited value in assessing prognosis. With the research on the molecular mechanisms of cancer and the development of advanced gene sequencing technology， it is now possible to reclassify cancer by studying the cancer genome atlas （TCGA）. This new classification method can help doctors to conduct more accurate risk assessments， provide more effective personalized treatment plans for EC patients， and predict the prognosis of EC patients by using TCGA data， which is expected to improve the treatment outcomes and survival rates of EC patients. This paper summarized the related research on molecular typing in EC at home and abroad， in order to provide new guidance and ideas for the diagnosis and treatment of EC in clinical practice.

关键词

子宫内膜癌癌症基因组图谱分子分型ProMisE

Keywords

endometrial cancerthe cancer genome atlasmolecular typingProMisE

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