Research progress on the origin and mechanism of gastric squamous cell carcinoma

YAO Shi-wei; YU Han

doi:10.11659/jjssx.06E024081

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Research progress on the origin and mechanism of gastric squamous cell carcinoma

Gastroenterology and Hepatobiliology | 更新时间：2024-10-22

- Research progress on the origin and mechanism of gastric squamous cell carcinoma
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 10, Pages: 841-843(2024)
- 作者机构：
  
  梅州市人民医院胃肠外科，广东梅州 514031
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.06E024081
  CLC： R656.6
- Published：25 October 2024，
  
  Received：20 June 2024，
- 稿件说明：
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姚仕伟,余晗.胃鳞状细胞癌发生来源及机制研究进展[J].局解手术学杂志,2024,33(10):841-843.

YAO Shi-wei,YU Han.Research progress on the origin and mechanism of gastric squamous cell carcinoma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):841-843.
姚仕伟,余晗.胃鳞状细胞癌发生来源及机制研究进展[J].局解手术学杂志,2024,33(10):841-843. DOI： 10.11659/jjssx.06E024081.

YAO Shi-wei,YU Han.Research progress on the origin and mechanism of gastric squamous cell carcinoma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(10):841-843. DOI： 10.11659/jjssx.06E024081.

摘要

胃鳞状细胞癌是一种罕见的胃恶性肿瘤，由于其早期症状不明显，发现时多已处于晚期，因此其治疗效果欠佳、预后相对较差。虽然该疾病目前有明确的诊断标准，但是对于其发生来源和机制尚无明确统一的认识。目前关于胃鳞状细胞癌的发生机制，多数学者相对认可胃黏膜上皮鳞状细胞化生这一学说，其他学说如多能干细胞的转化、异位鳞状细胞、腺癌向鳞状细胞分化及其他原因引起的鳞状细胞癌发生等则仍需要更多的研究来进一步证明。本文主要对上述学说的发生来源和机制进行阐述总结，以期为后续的研究提供参考。

Abstract

Gastric squamous cell carcinoma is a rare gastric malignant tumor. Due to its unclear early symptoms， it is often discovered in the late stage， resulting in poor treatment outcomes and relatively poor prognosis. Although there are clear diagnostic criteria for the disease， there is no clear consensus of its source and mechanism. At present， regarding the pathogenesis of gastric squamous cell carcinoma， most scholars relatively agree with the theory of gastric mucosal squamous cell metaplasia. Other theories， such as pluripotent stem cell transformation， ectopic squamous cell differentiation， adenocarcinoma into squamous cell differentiation， and the occurrence of squamous cell carcinoma caused by other reasons， still need more research to further confirm. This paper mainly expounds and summarizes the origin and mechanism of the above theories， in order to provide reference for the subsequent research.

关键词

胃癌鳞状细胞癌发生来源机制

Keywords

gastric cancersquamous cell carcinomaoccurrence sourcemechanism

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