Research progress on the relationship between CENPA expression and cancer
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 11, Pages: 1021-1024(2023)
- 作者机构：
1.青海大学研究生院，青海 西宁810000
2.青海大学附属医院病理科，青海 西宁 810000
- 作者简介：
- 基金信息：
DOI：10.11659/jjssx.05E023092
CLC： R730Published：25 November 2023，
Received：21 May 2023，
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王蓝天,张易青.CENPA表达与癌症的关系研究进展[J].局解手术学杂志,2023,32(11):1021-1024.
WANG Lan-tian,ZHANG Yi-qing.Research progress on the relationship between CENPA expression and cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(11):1021-1024.
王蓝天,张易青.CENPA表达与癌症的关系研究进展[J].局解手术学杂志,2023,32(11):1021-1024. DOI： 10.11659/jjssx.05E023092.
WANG Lan-tian,ZHANG Yi-qing.Research progress on the relationship between CENPA expression and cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(11):1021-1024. DOI： 10.11659/jjssx.05E023092.
摘要
异常的细胞分裂导致整个染色体不稳定是癌症发生的标志。染色体准确分离在细胞分裂中有着重要作用，而着丝粒则是染色体准确分离的关键。着丝粒蛋白A
（
CENPA）是一种着丝粒特异性组蛋白H3样变异基因，也是着丝粒蛋白家族中研究最广泛的因子，在多种癌症中过表达。CENPA过表达可能导致着丝粒异染色质沿染色体臂扩散，导致微管-动粒锚定缺陷，最终导致基因组不稳定。因此，探讨CENPA过表达与癌症进展的关系，对寻找新的靶向治疗方法有着重要意义。
Abstract
The instability of the entire chromosome caused by abnormal cell division is a hallmark of cancer development. Accurate segregation of chromosomes plays a critical role in cell division， while the centromere is the key to accurate chromosome segregation. The centromere protein A （CENPA）， as a centromere-specific histone H3-like variant gene and the most widely studied factor in the centromere protein family， is overexpressed in a variety of cancers. CENPA overexpression may lead to the proliferation of centromere heterochromatin along chromosomal arms， resulting in microtubule-kinetochore anchoring defects and ultimately genomic instability. Therefore， it is crucial to explore the relationship between CENPA overexpression and cancer progression for finding new targeted therapies.
关键词
着丝粒着丝粒蛋白AHolliday交叉识别蛋白癌症染色体不稳定
Keywords
centromerecentromere proteinAHolliday junction recognition proteincancerchromosome instability
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