Correlation between tear inflammatory factors and postoperative complications in glaucoma patients after trabeculectomy

doi:10.11659/jjssx.03E023150

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Correlation between tear inflammatory factors and postoperative complications in glaucoma patients after trabeculectomy

Clinical Research | 更新时间：2024-04-01

- Correlation between tear inflammatory factors and postoperative complications in glaucoma patients after trabeculectomy
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 3, Pages: 247-250(2024)
- 作者机构：
  
  1.张家港市中医医院眼科，江苏张家港 215600
  2.中国中医科学院眼科医院眼表科，北京 100040
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.03E023150
  CLC： R779.6
- Published：25 March 2024，
  
  Received：23 March 2023，
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张宇,赵庆一,吴宁玲等.青光眼患者小梁切除术后泪液炎症因子与术后并发症的相关性分析[J].局解手术学杂志,2024,33(03):247-250.

.Correlation between tear inflammatory factors and postoperative complications in glaucoma patients after trabeculectomy[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(03):247-250.
张宇,赵庆一,吴宁玲等.青光眼患者小梁切除术后泪液炎症因子与术后并发症的相关性分析[J].局解手术学杂志,2024,33(03):247-250. DOI： 10.11659/jjssx.03E023150.

.Correlation between tear inflammatory factors and postoperative complications in glaucoma patients after trabeculectomy[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(03):247-250. DOI： 10.11659/jjssx.03E023150.

摘要

目的

探讨泪液炎症因子在早期评估青光眼患者小梁切除术后并发症发生的应用价值。

方法

纳入在张家港市中医医院眼科接受小梁切除术的闭角型青光眼患者150例（共150眼）。收集所有患者临床资料，术前采集患者泪液，检测泪液中的炎症因子（G-CSF、GM-CSF、IFN-γ、MCP-1、TNF-α、IL-12、IL-13、IL-15、IL-1β、IL-4、IL-7、IL-10、IL-17、IL-5）水平。根据术后并发症发生情况将患者分为并发症组和对照组，对比2组患者临床资料，采用

Logistic

回归分析青光眼患者小梁切除术后发生并发症的相关因素；通过

Logistic

回归建立泪液炎症因子预测模型，绘制受试者工作特征（

ROC

）曲线分析该模型在早期评估青光眼患者小梁切除术后并发症发生的价值。

结果

150例青光眼患者小梁切除术后有35例（23.33%）发生并发症，其中浅前房24例，睫状体或脉络膜脱离5例，虹膜睫状体炎3例，前房积血2例，视网膜脱离1例。并发症组患者IFN-γ、GM-CSF和IL-5水平低于对照组（

0.05）；2组患者其余炎症因子比较，差异无统计学意义（

0.05）。多因素

Logistic

回归分析显示，IFN-γ升高（

=0.999）、GM-CSF升高（

=0.988）和IL-5升高（

=0.996）是青光眼患者小梁切除术后并发症发生的独立保护因素（

0.05）；

ROC

曲线分析显示，该模型在早期评估青光眼患者小梁切除术后并发症发生的敏感度为94.29%，特异度为83.84%，

AUC

为0.906，高于IFN-γ（

AUC

=0.642）、GM-CSF（

AUC

=0.721）和IL-5（

AUC

=0.666）单独预测。

结论

术前分析青光眼患者的泪液炎症因子能够早期评估术后并发症的发生情况，特别是IFN-γ、GM-CSF和IL-5水平联合检测对于预测术后并发症的发生具有重要意义。

Abstract

Objective

To investigate the application value of tear inflammatory factors in early evaluation of the occurrence of complications after trabeculectomy in glaucoma patients.

Methods

A total of 150 eyes of 150 patients with angle-closure glaucoma who underwent trabeculectomy in Department of Ophthalmology of Zhangjiagang Hospital of Traditional Chinese Medicine were included.The clinical data of all patients were collected，and the levels of inflammatory factors （including G-CSF，GM-CSF，IFN-γ，MCP-1，TNF-α，IL-12，IL-13，IL-15，IL-1β，IL-4，IL-7，IL-10，IL-17，IL-5） in tears were detected before surgery.According to the occurrence of postoperative complications，the patients were divided into the complication group and the control group，and the clinical data of the two groups were compared.

Logistic

regression was used to analyze the related factors of the occurrence of complications after trabeculectomy in glaucoma patients.The predictive model of tear inflammatory factors was established by

Logistic

regression，and the

receiver operating characteristic

（

ROC

） curve was drawn to analyze the value of this model in early evaluation of the occurrence of complications after trabeculectomy in glaucoma patients.

Results

Complications occurred in 35 （23.33%） of 150 glaucoma patients after trabeculectomy，including 24 cases of shallow anterior chamber，5 cases of ciliary body or choroid detachment，3 cases of iridocyclitis，2 cases of hyphema，and 1 case of retinal detachment. IFN-γ，GM-CSF and IL-5 levels of the patients in the complication group were lower than those in the control group （

0.05）.There was no significant difference in the levels of other inflammatory factors of patients between the two groups （

0.05）.Multivariate

Logistic

regression analysis showed that increased levels of IFN-γ （

=0.999），GM-CSF （

=0.988） and IL-5 （

=0.996） were independent protective factors for complications after trabeculectomy in glaucoma patients （

0.05）.

ROC

curve analysis showed that the sensitivity and specificity of the model were 94.29% and 83.84% in early evaluation of the occurrence of complications after trabeculectomy in glaucoma patients，and the

AUC

was 0.906，which was higher than that predicted by IFN-γ （

AUC

=0.642），GM-CSF （

AUC

=0.721） and IL-5 （

AUC

=0.666） alone.

Conclusion

Preoperative analysis of tear inflammatory factors in glaucoma patients can early evaluate the occurrence of postoperative complications，especially the combined detection of IFN-γ，GM-CSF and IL-5 levels is of great significance for predicting the occurrence of complications.

关键词

青光眼泪液小梁切除术并发症炎症因子

Keywords

glaucomatear fluidtrabeculectomycomplicationsinflammatory factors

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