Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty

WANG Wen-can; ZHANG Yu; LI Pei-yu

doi:10.11659/jjssx.02E023102

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Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty

Clinical Research | 更新时间：2024-02-02

- Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 2, Pages: 133-136(2024)
- 作者机构：
  
  四川省骨科医院麻醉科，四川成都 610000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.02E023102
  CLC： R614
- Published：25 February 2024，
  
  Received：19 February 2023，
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王文璨,张宇,李培玉.小剂量艾司氯胺酮和舒芬太尼在髋关节置换术围术期镇痛中的效果比较[J].局解手术学杂志,2024,33(02):133-136.

WANG Wen-can,ZHANG Yu,LI Pei-yu.Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(02):133-136.
王文璨,张宇,李培玉.小剂量艾司氯胺酮和舒芬太尼在髋关节置换术围术期镇痛中的效果比较[J].局解手术学杂志,2024,33(02):133-136. DOI： 10.11659/jjssx.02E023102.

WANG Wen-can,ZHANG Yu,LI Pei-yu.Comparison of effects of low-dose esketamine and sufentanil on perioperative analgesia for hip arthroplasty[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(02):133-136. DOI： 10.11659/jjssx.02E023102.

摘要

目的

对比小剂量艾司氯胺酮和舒芬太尼在髋关节置换术（HA）患者围术期镇痛中的应用效果。

方法

将我院行HA的124例患者按照随机数字表法分为对照组和观察组，每组62例。对照组患者使用舒芬太尼进行镇痛；观察组患者使用小剂量艾司氯胺酮镇痛。观察2组患者麻醉前（T1）、手术切皮时（T2）、麻醉30 min后（T3）及手术结束时（T4）的心率（HR）、呼吸频率（RR）、平均动脉压（MAP）、血氧饱和度（SpO

）等血流动力学变化；于术前（T5）、术后6 h（T6）、术后12 h（T7）及术后24 h（T8）记录患者静息状态及活动状态下疼痛视觉模拟量表（visual analogue scale

VAS）评分；统计2组患者术后镇痛泵按压次数，需补充镇痛药物情况，术中及术后24 h不良反应发生情况。

结果

2组患者T1时HR、MAP及RR水平比较，差异无统计学意义（

0.05）；观察组患者T2、T3、T4时HR、MAP及RR水平均高于对照组（

0.05）；2组患者各时间段SpO

水平比较差异无统计学意义（

0.05）。2组患者T5时静息状态及活动状态VAS评分比较差异无统计学意义（

0.05）；观察组患者T6、T7、T8时静息状态及活动状态VAS评分均低于对照组（

0.05）。观察组术后镇痛泵按压次数及需补充镇痛药物患者比例均少/低于对照组（

0.05）。2组术中及术后不良反应发生率比较，差异无统计学意义（

0.05）。

结论

与舒芬太尼相比，小剂量艾司氯胺酮应用于HA患者的镇痛效果更好，患者围术期疼痛程度更轻，术中血流动力学更稳定，安全性较好。

Abstract

Objective

To compare the application effects of low-dose esketamine and sufentanil on perioperative analgesia in patients undergoing hip arthroplasty （HA）.

Methods

A total of 124 patients who underwent HP in our hospital were divided into the control group and the observation group according to random number table，with 62 cases in each group. Patients in the control group were given sufentanil for analgesia，and patients in the observation group were given low-dose esketamine for analgesia. The hemodynamics changes of the heart rate （HR），respiratory rate （RR），mean arterial pressure （MAP） and oxygen saturation （SpO

） of patients before anesthesia （T

），at the time of incising skin （T2），after 30 minutes of anesthesia （T3） and at the end of surgery （T4） in both groups were observed. The visual analogue scale （VAS） scores of patients in resting state and active state before surgery （T5），6 hours after surgery （T6），12 hours after surgery （T7） and 24 hours after surgery （T8） were recorded. The number of postoperative analgesic pump compression，need of supplemental analgesic drugs and occurrence of adverse reactions during surgery and 24 hours after surgery of patients in the two groups were recorded.

Results

There was no statistically significant difference in HR，MAP or RR at T1 of patients between the two groups （

0.05）. The levels of HR，MAP and RR at T2，T3 and T4 of patients in the observation group were higher than those in the control group （

0.05）. There was no statistically significant difference in SpO

at each time points between the two groups （

0.05）. There was no statistically significant difference in the VAS scores at T5 of patients in resting state or active state （

0.05）. The VAS scores at T6，T7 and T8 of patients in resting state and active state in the observation group were lower than those in the control group （

0.05）. The number of postoperative analgesic pump compression and the proportion of patients with the need of supplemental analgesic drugs in the observation group were less/lower than those in the control group （

0.05）. There was no statistically significant difference in the incidence of intraoperative and postoperative adverse reactions of patients between the two groups （

0.05）.

Conclusion

Compared with sufentanil，low-dose esketamine has better analgesic effect for IA patients，with milder perioperative pain degree，more stable intraoperative hemodynamics，and better safety.

关键词

艾司氯胺酮舒芬太尼髋关节置换术镇痛

Keywords

esketaminesufentanilhip arthroplastyanalgesia

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