Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis

RAO Hui; JIANG Sheng-zhi; FAN Yu-bei; ZHOU Yu-qing; ZHANG Li-hua

doi:10.11659/jjssx.01E023100

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Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis

Clinical Research | 更新时间：2024-02-02

- Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 33, Issue 2, Pages: 137-139(2024)
- 作者机构：
  
  湖南师范大学附属第一医院风湿免疫科，湖南长沙 410001
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.01E023100
  CLC： R593.22;R446.41
- Published：25 February 2024，
  
  Received：31 January 2023，
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饶慧,蒋盛芝,樊谕蓓等.类风湿关节炎血清miR-410-3p表达与膝关节软组织病变的关系[J].局解手术学杂志,2024,33(02):137-139.

RAO Hui,JIANG Sheng-zhi,FAN Yu-bei,et al.Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(02):137-139.
饶慧,蒋盛芝,樊谕蓓等.类风湿关节炎血清miR-410-3p表达与膝关节软组织病变的关系[J].局解手术学杂志,2024,33(02):137-139. DOI： 10.11659/jjssx.01E023100.

RAO Hui,JIANG Sheng-zhi,FAN Yu-bei,et al.Relationship between serum miR-410-3p expression and knee soft tissue lesions in patients with rheumatoid arthritis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2024,33(02):137-139. DOI： 10.11659/jjssx.01E023100.

摘要

目的

探究类风湿关节炎（RA）患者血清miR-410-3p的表达及其与膝关节软组织病变的关系。

方法

选取我院收治的RA患者89例，根据28个关节疾病活动度评分（DAS28）将其分为活动组（42例）、缓解组（47例）；另选取同期体检健康志愿者52例为健康组。RT-PCR法检测血清miR-410-3p的表达水平；超声检查膝关节软组织病变情况；采用

Pearson

法分析血清miR-410-3p表达与膝关节软组织病变的关系。

结果

活动组和缓解组患者血清miR-410-3p表达水平均低于健康组（

0.05），活动组患者血清miR-410-3p表达水平低于缓解组（

0.05）。活动组和缓解组患者股骨内、外侧踝软骨厚度均小于健康组（

0.05），且活动组患者上述指标小于缓解组（

0.05）；活动组和缓解组患者髌上囊液体深度、滑膜厚度大于健康组（

0.05），且活动组患者髌上囊液体深度、滑膜厚度大于缓解组（

0.05）。RA患者血清miR-410-3p水平与髌上囊液体深度和滑膜厚度呈正相关（

0.05），与股骨内、外侧踝软骨厚度呈负相关（

0.05）。

结论

RA患者血清miR-410-3p表达水平降低，且与膝关节软组织病变密切相关，检测血清miR-410-3p水平变化可为评估膝关节软组织病变提供参考。

Abstract

Objective

To explore the expression of serum miR-410-3p in patients with rheumatoid arthritis （RA） and its relationship with knee soft tissue lesions.

Methods

A total of 89 RA patients admitted to our hospital were selected and divided into the active group （42 cases） and the remission group （47 cases） according to disease activity score in 28 joints （DAS28）. In addition，52 healthy volunteers underwent physical examination during the same period in our hospital were selected as the healthy group. The expression level of serum miR-410-3p was detected by RT-PCR，the lesions of knee soft tissue was examined by ultrasound，and the relationship between the expression of serum miR-410-3p and knee soft tissue lesions was analyzed by

Pearson

Results

The expression levels of serum miR-410-3p of patients in the active group and the remission group were lower than that in the healthy group （

0.05），and the expression level of serum miR-410-3p of patients in the active group was lower than that in the remission group （

0.05）. The cartilage thicknesses of medial and lateral ankle of patients in the active group and the remission group were smaller than those in the healthy group （

0.05），and the above indexes in the active group were smaller than those in the remission group （

0.05）. The depths of suprapatellar bursa fluid and synovial thicknesses of patients in the active group and the remission group were greater than those in the healthy group （

0.05），and the depth of suprapatellar bursa fluid and synovial thickness of patients in the active group were greater than those in the remission group （

0.05）. The level of serum miR-410-3p in RA patients was positively correlated with the depth of suprapatellar bursa fluid and synovial thickness （

0.05），and negatively correlated with the cartilage thicknesses of medial and lateral ankle （

0.05）.

Conclusion

Serum miR-410-3p expression level in RA patients is decreased，which was closely related to knee soft tissue lesions，detecting the changes of serum miR-410-3p level may provide a reference for the evaluation of knee soft tissue lesions.

关键词

类风湿关节炎miR-410-3p膝关节软组织病变

Keywords

rheumatoid arthritismiR-410-3pknee soft tissue lesions

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