Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Yunchao Zhang; Jiayu Tang; Cheng Wang; Qinxiu Zhang; Anqi Zeng; Linjiang Song

doi:10.1016/j.gendis.2023.04.015

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Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Review article | 更新时间：2024-02-04

- Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword
- Genes & Diseases Vol. 1, Issue 1, Pages: 367-381(2024)
- 作者机构：
  
  1. School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine,Sichuan,Chengdu,China,611137
  2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Sichuan,Chengdu,China,611137
  3. Institute of Translational Pharmacology and Clinical Application, Sichuan Academy of Chinese Medical Science,Sichuan,Chengdu,China,610041
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.04.015
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Yunchao Zhang, Jiayu Tang, Cheng Wang, et al. Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword. [J]. Genes & Diseases 1(1):367-381(2024)
DOI：

Yunchao Zhang, Jiayu Tang, Cheng Wang, et al. Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword. [J]. Genes & Diseases 1(1):367-381(2024) DOI： 10.1016/j.gendis.2023.04.015.

摘要

Abstract

The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate of cancer patients is still unsatisfactory. Therefore

it is necessary to further elucidate the molecular mechanisms involved in tumor development and drug resistance to improve cancer cure or survival rates. In recent years

autophagy has become a hot topic in the field of oncology research

which plays a double-edged role in tumorigenesis

progression

and drug resistance. Meanwhile

long non-coding RNA (lncRNA) has also been shown to regulate autophagy

and the two-sided nature of autophagy determines the dual regulatory role of autophagy-related lncRNAs (ARlncRNAs). Therefore

ARlncRNAs can be effective therapeutic targets for various cancers. Furthermore

the high abundance and stability of ARlncRNAs in tumor tissues make them promising biomarkers. In this review

we summarized the roles and mechanisms of ARlncRNAs in tumor cell proliferation

apoptosis

migration

invasion

drug resistance

angiogenesis

radiation resistance

and immune regulation. In addition

we described the clinical significance of these ARlncRNAs

including as biomarkers/therapeutic targets and their association with clinical drugs.

关键词

Keywords

ApoptosisAutophagyBiomarkerCancerDrug resistanceLncRNA

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Ministry of Education Key Laboratory of Diagnostic Medicine, Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center

Departments of Orthopedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University

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