DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

Qiuxia Cui; Jian Sun; Jingping Yuan; Juanjuan Li; Chuanyu Yang; Guangshi Du; Chengang Zhou; Pu Qiu; Jidong Gao; Yuanqi Zhang; Dewei Jiang; Ceshi Chen

doi:10.1016/j.gendis.2023.03.028

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DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

Short communication | 更新时间：2024-02-04

- DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
- Genes & Diseases Vol. 1, Issue 1, Pages: 91-94(2024)
- 作者机构：
  
  1. Affiliated Hospital of Guangdong Medical University Science & Technology of China,Guangdong,Zhanjiang,China,524000
  2. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Guangdong,Shenzhen,China,518116
  3. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences,Yunnan,Kunming,China,650223
  4. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China,100021
  5. Department of Pathology, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430060
  6. Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430060
  7. Translational Medicine Research Center of Guizhou Medical University,Guizhou,Guiyang,China,550025
  8. Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center,Yunnan,Kunming,China,650500
  9. Academy of Biomedical Engineering, Kunming Medical University,Yunnan,Kunming,China,650500
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.028
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Qiuxia Cui, Jian Sun, Jingping Yuan, et al. DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis. [J]. Genes & Diseases 1(1):91-94(2024)
DOI：

Qiuxia Cui, Jian Sun, Jingping Yuan, et al. DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis. [J]. Genes & Diseases 1(1):91-94(2024) DOI： 10.1016/j.gendis.2023.03.028.

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1 W.D. Foulkes, I.E. Smith, J.S. Reis-FilhoTriple-negative breast cancer N Engl J Med, 363 (20) (2010), pp. 1938-1948

2 C.H. Chen, N. Yang, Y. Zhang, et al.Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers Int J Biol Sci, 15 (8) (2019), pp. 1733-1742

3 M.C.W. van den Berg, B.M.T. BurgeringIntegrating opposing signals toward Forkhead box O Antioxidants Redox Signal, 14 (4) (2011), pp. 607-621

4 J.M. Yu, W. Sun, Z.H. Wang, et al.TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription Nat Commun, 10 (1) (2019), p. 5720

5 I.D. Kyriazis, M. Hoffman, L. Gaignebet, et al.KLF5 is induced by FOXO1 and causes oxidative stress and diabetic cardiomyopathy Circ Res, 128 (3) (2021), pp. 335-357

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