Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis

Xinrui Dong; Ye Li; Xiaonan Sheng; Weihang Zhou; Aijun Sun; Huijuan Dai

doi:10.1016/j.gendis.2023.03.019

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Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis

Review article | 更新时间：2024-02-04

- Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis
- Genes & Diseases Vol. 1, Issue 1, Pages: 358-366(2024)
- 作者机构：
  
  1. Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University,Shanghai,China,200127
  2. Department of Thyroid and Breast Oncological Surgery, Xuzhou Medical College Affiliated Huaian Hospital,Jiangsu,Huai'an,China,223001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.019
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Xinrui Dong, Ye Li, Xiaonan Sheng, et al. Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis. [J]. Genes & Diseases 1(1):358-366(2024)
DOI：

Xinrui Dong, Ye Li, Xiaonan Sheng, et al. Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis. [J]. Genes & Diseases 1(1):358-366(2024) DOI： 10.1016/j.gendis.2023.03.019.

摘要

Abstract

Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid peroxidation. The core organelle involved in ferroptosis is mitochondria. Mitochondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology

biochemistry

gene expression

and energy metabolism. An increasing number of studies have shown that mitochondria and their associated metabolic pathways mediate ferroptosis in the development and progression of breast cancer. In this review

we discuss the relevant research about ferroptosis in breast cancer and provide a comprehensive summary of mitochondrial regulation in ferroptosis from the perspective of lipid metabolism

oxidative phosphorylation

ion metabolism

glycometabolism

and nucleotide metabolism. We also summarize the application of mitochondrial metabolism-related pathways as ferroptosis treatment targets. Here we provide new insights into the relationship between mitochondria

ferroptosis

and breast cancer treatment.

关键词

Keywords

Breast cancerCancer treatmentFerroptosisLipid metabolismMitochondriaOxidative phosphorylation

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