Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Huanyu Luo; Anahid Ahmadi Birjandi; Feilong Ren; Tianmeng Sun; Paul T. Sharpe; Hongchen Sun; Zhengwen An

doi:10.1016/j.gendis.2023.03.015

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Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Review article | 更新时间：2024-02-04

- Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease
- Genes & Diseases Vol. 1, Issue 1, Pages: 346-357(2024)
- 作者机构：
  
  1. Department of Oral Biology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University,Jilin,Changchun,China,130021
  2. Faculty of Dentistry, Oral & Craniofacial Sciences, Centre for Craniofacial and Regenerative Biology, King's College London,London,UK,SE1 9RT
  3. Department of Oral Pathology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University,Jilin,Changchun,China,130021
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.015
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Huanyu Luo, Anahid Ahmadi Birjandi, Feilong Ren, et al. Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease. [J]. Genes & Diseases 1(1):346-357(2024)
DOI：

Huanyu Luo, Anahid Ahmadi Birjandi, Feilong Ren, et al. Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease. [J]. Genes & Diseases 1(1):346-357(2024) DOI： 10.1016/j.gendis.2023.03.015.

摘要

Abstract

Extracellular vesicles (EVs) are nano-size vesicles secreted naturally by all cells into the extracellular space and have been recognized as important cell–cell mediators in multicellular organisms. EVs contain nucleic acids

proteins

lipids

and other cellular components

regulating many basic biological processes and playing an important role in regenerative medicine and diseases. EVs can be traced to their cells of origin and exhibit a similar function. Moreover

EVs demonstrate low immunogenicity

good biocompatibility

and fewer side effects

compared to their parent cells. Mesenchymal stem cells (MSCs) are one of the most important resource cells for EVs

with a great capacity for self-renewal and multipotent differentiation

and play an essential role in stem cell therapy. The mechanism of MSC therapy was thought to be attributed to the differentiation of MSCs after targeted migration

as previously noted. However

emerging evidence shows the previously unknown role of MSC-derived paracrine factors in stem cell therapy. Especially EVs derived from oral tissue MSCs (OMSC-EVs)

show more advantages than those of all other MSCs in tissue repair and regeneration

due to their lower invasiveness and easier accessibility for sample collection. Here

we systematically review the biogenesis and biological characteristics of OMSC-EVs

as well as the role of OMSC-EVs in intercellular communication. Furthermore

we discuss the potential therapeutic roles of OMSC-EVs in oral and systemic diseases. We highlight the current challenges and future directions of OMSC-EVs to focus more attention on clinical translation. We aim to provide valuable insights for the explorative clinical application of OMSC-EVs.

关键词

Keywords

DiseaseExtracellular vesiclesOral tissue MSCTherapeutic applicationTissue regeneration

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