Effects of microenvironment and biological behavior on the paracrine function of stem cells

Zhixin Xue; Yunjun Liao; Ye Li

doi:10.1016/j.gendis.2023.03.013

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Effects of microenvironment and biological behavior on the paracrine function of stem cells

Review article | 更新时间：2024-02-04

- Effects of microenvironment and biological behavior on the paracrine function of stem cells
- Genes & Diseases Vol. 1, Issue 1, Pages: 135-147(2024)
- 作者机构：
  
  The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University,Guangdong,Guangzhou,China,510515
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.013
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Zhixin Xue, Yunjun Liao, Ye Li. Effects of microenvironment and biological behavior on the paracrine function of stem cells. [J]. Genes & Diseases 1(1):135-147(2024)
DOI：

Zhixin Xue, Yunjun Liao, Ye Li. Effects of microenvironment and biological behavior on the paracrine function of stem cells. [J]. Genes & Diseases 1(1):135-147(2024) DOI： 10.1016/j.gendis.2023.03.013.

摘要

Abstract

Mesenchymal stem cells (MSCs)

the most well-studied cell type in the field of stem cell therapy

have multi-lineage differentiation and self-renewal potential. MSC-based therapies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function. An increasing body of evidence demonstrates that paracrine function is central to the effects of MSC-based therapy. Growth factors

cytokines

chemokines

extracellular matrix components

and extracellular vehicles all contribute to the beneficial effects of MSCs on tissue regeneration and repair. The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior. In this review

we discuss the bioactive substances secreted by MSCs depending on the microenvironment and biological behavior and their regulatory mechanisms

which explain their potential to treat human diseases

to provide new ideas for further research and clinical cell-free therapy.

关键词

Keywords

Bioactive behaviormesenchymal stem cellsMicroenvironmentParacrineSecretome

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