Hypermethylation of the <em>ALOX12</em> and <em>CBS</em> promoters in osteoporosis: Potential biomarkers for early diagnosis

Shang Guo; Yue Wu; Weekai Chia; Peichun Hsu; Hongwei Wang; Yunliang Wang; Biao Zhong

doi:10.1016/j.gendis.2023.03.005

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Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis

Short communication | 更新时间：2024-02-04

- Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis
- Genes & Diseases Vol. 1, Issue 1, Pages: 30-33(2024)
- 作者机构：
  
  1. Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China,200023
  2. Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM),Shanghai,China,200025
  3. The University of Chicago, Department of Medicine,IL,Chicago,USA,60637
  4. Department of Neurology, The Second Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou,China,450014
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.005
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Shang Guo, Yue Wu, Weekai Chia, et al. Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis. [J]. Genes & Diseases 1(1):30-33(2024)
DOI：

Shang Guo, Yue Wu, Weekai Chia, et al. Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis. [J]. Genes & Diseases 1(1):30-33(2024) DOI： 10.1016/j.gendis.2023.03.005.

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1 F. Marini, L. Cianferotti, M.L. BrandiEpigenetic mechanisms in bone biology and osteoporosis: can they drive therapeutic choices? Int J Mol Sci, 17 (8) (2016), p. 1329

2 W.J. Xiao, J.W. He, H. Zhang, et al.ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families Int J Obes, 35 (3) (2011), pp. 378-386

3 A. Al-E-Ahmad, H. Parsian, M. Fathi, et al.ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients Adv Clin Exp Med, 27 (12) (2018), pp. 1717-1722

4 T. Majtan, H. Hůlková, I. Park, et al.Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria FASEB J, 31 (12) (2017), pp. 5495-5506

5 Y.M. Hao, D.W. He, Y. Gao, et al.Association of hydrogen sulfide with femoral bone mineral density in osteoporosis patients: a preliminary study Med Sci Monit, 27 (2021), Article e929389

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