Hepatocyte-specific deletion of <em>Mettl3</em> promotes hepatocellular carcinoma in mice

Chunhong Liu; Xinzhi Li; Zhicheng Yao; Xueying Li; Zheng Chen

doi:10.1016/j.gendis.2023.02.048

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Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice

Short communication | 更新时间：2024-02-04

- Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice
- Genes & Diseases Vol. 1, Issue 1, Pages: 57-59(2024)
- 作者机构：
  
  1. HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology,Heilongjiang,Harbin,China,150001
  2. Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510530
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.048
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Chunhong Liu, Xinzhi Li, Zhicheng Yao, et al. Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice. [J]. Genes & Diseases 1(1):57-59(2024)
DOI：

Chunhong Liu, Xinzhi Li, Zhicheng Yao, et al. Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice. [J]. Genes & Diseases 1(1):57-59(2024) DOI： 10.1016/j.gendis.2023.02.048.

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1 J. Liu, Y. Yue, D. Han, et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation Nat Chem Biol, 10 (2) (2014), pp. 93-95

2 M. Chen, L. Wei, C.T. Law, et al.RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2 Hepatology, 67 (6) (2018), pp. 2254-2270

3 X. Li, B. Yuan, M. Lu, et al.The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression Nat Commun, 12 (1) (2021), p. 7213

4 Y. Wang, M. Gao, F. Zhu, et al.METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice Nat Commun, 11 (1) (2020), p. 1648

5 X. Li, Y. Jiang, X. Sun, et al.METTL3 is required for maintaining β-cell function Metabolism, 116 (2021), p. 154702

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Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice

DOI：10.1016/j.gendis.2023.02.048

摘要

Abstract

关键词

Keywords

references