Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

Souvik Kar; Andrea Perrelli; Kiran Kumar Bali; Raffaella Mastrocola; Arpita Kar; Bushra Khan; Luis Gand; Arnab Nayak; Christian Hartmann; Wolfram S. Kunz; Amir Samii; Helmut Bertalanffy; Saverio Francesco Retta

doi:10.1016/j.gendis.2023.02.045

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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

Short communication | 更新时间：2024-02-04

- Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease
- Genes & Diseases Vol. 1, Issue 1, Pages: 67-71(2024)
- 作者机构：
  
  1. International Neuroscience Institute, Rudolf-Pichlmayr-Strasse 4,Hannover,Germany,30625
  2. Department of Clinical and Biological Sciences, University of Torino, Orbassano (TO),Italy,10043
  3. CCM Italia Research Network, National Coordination Center at the Department of Clinical and Biological Sciences, University of Torino, Orbassano (TO),Italy,10043
  4. Department of Pharmacology and Physiology, University of Rochester Medical Center,NY,Rochester,USA,14642
  5. Department of Experimental Pain Research, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University,Mannheim,Germany,68167
  6. Department of Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School,Hannover,Germany,30625
  7. Ricarda-Huch-Street-10B,Hannover,Germany,30880
  8. Institute of Molecular and Cell Physiology, Hannover Medical School,Hannover,Germany,30625
  9. Department of Neuropathology, Institute of Pathology, Hannover Medical School,Hannover,Germany,30625
  10. Institute of Experimental Epileptology and Cognition Research and Department of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn,Germany,53127
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.045
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Souvik Kar, Andrea Perrelli, Kiran Kumar Bali, et al. Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease. [J]. Genes & Diseases 1(1):67-71(2024)
DOI：

Souvik Kar, Andrea Perrelli, Kiran Kumar Bali, et al. Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease. [J]. Genes & Diseases 1(1):67-71(2024) DOI： 10.1016/j.gendis.2023.02.045.

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1 A. Perrelli, S.F. RettaPolymorphisms in genes related to oxidative stress and inflammation: emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease Free Radic Biol Med, 172 (2021), pp. 403-417

2 A. Perrelli, C. Ferraris, E. Berni, et al.KRIT1: a traffic warden at the busy crossroads between redox signaling and the pathogenesis of cerebral cavernous malformation disease Antioxidants Redox Signal, 38 (7–9) (2023), pp. 496-528

3 A. Venkatraman, S. Hardas, N. Patel, et al.Galectin-3: an emerging biomarker in stroke and cerebrovascular diseases Eur J Neurol, 25 (2) (2018), pp. 238-246

4 S. Subhash, N. Kalmbach, F. Wegner, et al.Transcriptome-wide profiling of cerebral cavernous malformations patients reveal important long noncoding RNA molecular signatures Sci Rep, 9 (1) (2019), Article 18203

5 M. Burguillos, M. Svensson, T. Schulte, et al.Microglia-secreted galectin-3 acts as a Toll-like receptor 4 ligand and contributes to microglial activation Cell Rep, 10 (9) (2015), pp. 1626-1638

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