HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

Yan Zhao; Cheng Xing; Yating Deng; Can Ye; Hongling Peng

doi:10.1016/j.gendis.2023.02.039

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HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

Review article | 更新时间：2024-02-04

- HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies
- Genes & Diseases Vol. 1, Issue 1, Pages: 234-251(2024)
- 作者机构：
  
  1. Department of Hematology, The Second Xiangya Hospital, Central South University,Hunan,Changsha,China,410011
  2. Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University,Hunan,Changsha,China,410011
  3. Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies, The Second Xiangya Hospital, Central South University,Hunan,Changsha,China,410011
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.039
  CLC：
- Published：2024，
  
  Published Online：1 January 2024，
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Yan Zhao, Cheng Xing, Yating Deng, et al. HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies. [J]. Genes & Diseases 1(1):234-251(2024)
DOI：

Yan Zhao, Cheng Xing, Yating Deng, et al. HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies. [J]. Genes & Diseases 1(1):234-251(2024) DOI： 10.1016/j.gendis.2023.02.039.

摘要

Abstract

The hypoxic microenvironment is an essential characteristic of most malignant tumors. Notably

hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular adaptation to hypoxia

and many critical pathways are correlated with the biological activity of organisms via HIF-1α. In the intra-tumoral hypoxic environment

HIF-1α is highly expressed and contributes to the malignant progression of tumors

which in turn results in a poor prognosis in patients. Recently

it has been indicated that HIF-1α involves in various critical processes of life events and tumor development via regulating the expression of HIF-1α target genes

such as cell proliferation and apoptosis

angiogenesis

glucose metabolism

immune response

therapeutic resistance

etc

. Apart from solid tumors

accumulating evidence has revealed that HIF-1α is also closely associated with the development and progression of hematological malignancies

such as leukemia

lymphoma

and multiple myeloma. Targeted inhibition of HIF-1α can facilitate an increased sensitivity of patients with malignancies to relevant therapeutic agents. In the review

we elaborated on the basic structure and biological functions of HIF-1α and summarized their current role in various malignancies. It is expected that they will have future potential for targeted therapy.

关键词

Keywords

AngiogenesisHematological malignanciesHypoxia-inducible factor-1 alpha (HIF-1α)Immune escapeTargeted therapy

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