Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop

Xiang Qin; Yuchen He; Yixi Zhang; Shun Li; Tingting Li; Fengming You; Yiyao Liu

doi:10.1016/j.gendis.2023.02.037

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Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop

Short communication | 更新时间：2024-02-04

- Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop
- Genes & Diseases Vol. 1, Issue 6, Pages: 2199-2201(2023)
- 作者机构：
  
  1. Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Life Science and Technology, University of Electronic Science and Technology of China,Sichuan,Chengdu,China,611731
  2. TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine,Sichuan,Chengdu,China,610072
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.037
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Xiang Qin, Yuchen He, Yixi Zhang, et al. Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop. [J]. Genes & Diseases 1(6):2199-2201(2023)
DOI：

Xiang Qin, Yuchen He, Yixi Zhang, et al. Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop. [J]. Genes & Diseases 1(6):2199-2201(2023) DOI： 10.1016/j.gendis.2023.02.037.

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1 A. Yamamoto, A.E. Doak, K.J. CheungOrchestration of collective migration and metastasis by tumor cell clusters Annu Rev Pathol, 18 (2023), pp. 231-256

2 Z. Xin, K. Deguchi, S.I. Suye, et al.Quantitative analysis of collective migration by single-cell tracking aimed at understanding cancer metastasis Int J Mol Sci, 23 (20) (2022), p. 12372

3 Y. Peng, Z. Chen, Y. Chen, et al.ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness Acta Biomater, 88 (2019), pp. 86-101

4 X. Qin, B.O. Park, J. Liu, et al.Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation Nat Commun, 8 (2017), p. 14708

5 X. Qin, E. Hannezo, T. Mangeat, et al.A biochemical network controlling basal myosin oscillation Nat Commun, 9(1) (2018), p. 1210

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