Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

Qingtian Huang; Na Zhang; Jiangtuan Wang; Hua Xu; Leyi Yao; Qianqian Yang; Ding Yan; Xi Chen; Qian Xue; Min Xiao; Jiawen Wu; Xueheng Wu; Qin Liu; Daolin Tang; Xin Chen; Xiaofen Li; Jinbao Liu

doi:10.1016/j.gendis.2023.02.024

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Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

Short communication | 更新时间：2024-02-04

- Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages
- Genes & Diseases Vol. 1, Issue 6, Pages: 2222-2225(2023)
- 作者机构：
  
  1. Affiliated Cancer Hospital & Institute of Guangzhou Medical University,Guangdong,Guangzhou,China,510095
  2. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University,Guangdong,Guangzhou,China,511436
  3. Institute of Digestive Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital,Guangdong,Qingyuan,China,511518
  4. Department of Pathology, Dongguan People's Hospital Affiliated to Southern Medical University,Guangdong,Dongguan,China,523059
  5. Department of Surgery, UT Southwestern Medical Center,TX,Dallas,USA,75390
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.024
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Qingtian Huang, Na Zhang, Jiangtuan Wang, et al. Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages. [J]. Genes & Diseases 1(6):2222-2225(2023)
DOI：

Qingtian Huang, Na Zhang, Jiangtuan Wang, et al. Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages. [J]. Genes & Diseases 1(6):2222-2225(2023) DOI： 10.1016/j.gendis.2023.02.024.

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1 G.T. Stathopoulos, T.P. Sherrill, D.S. Cheng, et al.Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis Proc Natl Acad Sci U S A, 104 (47) (2007), pp. 18514-18519

2 R. Stocker, Y. Yamamoto, A.F. McDonagh, et al.Bilirubin is an antioxidant of possible physiological importance Science, 235 (4792) (1987), pp. 1043-1046

3 H. Huang, M. Guo, N. Liu, et al.Bilirubin neurotoxicity is associated with proteasome inhibition Cell Death Dis, 8 (6) (2017), Article e2877

4 A.M. Laughney, J. Hu, N.R. Campbell, et al.Regenerative lineages and immune-mediated pruning in lung cancer metastasis Nat Med, 26 (2) (2020), pp. 259-269

5 N. Kim, H.K. Kim, K. Lee, et al.Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma Nat Commun, 11 (1) (2020), p. 2285

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