Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

Meng Sha; Chuan Shen; Seogsong Jeong; Ning Xu; Chen Chen; Hua-lian Hang; Ying Tong; Jie Cao

doi:10.1016/j.gendis.2023.02.023

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Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

Short communication | 更新时间：2024-02-04

- Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma
- Genes & Diseases Vol. 1, Issue 6, Pages: 2226-2228(2023)
- 作者机构：
  
  1. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,China,200127
  2. Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam 13488, Republic of Korea
  3. Institute of Basic Medical Sciences, School of Medicine, CHA University, Seongnam 13488, Republic of Korea
  4. Institute for Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, Republic of Korea
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.023
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Meng Sha, Chuan Shen, Seogsong Jeong, et al. Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma. [J]. Genes & Diseases 1(6):2226-2228(2023)
DOI：

Meng Sha, Chuan Shen, Seogsong Jeong, et al. Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma. [J]. Genes & Diseases 1(6):2226-2228(2023) DOI： 10.1016/j.gendis.2023.02.023.

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1 M. Sha, S. Jeong, X. Wang, et al.Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma BMC Cancer, 19 (1) (2019), p. 208

2 G. Valenti, H.M. Quinn, G.J.J.E. Heynen, et al.Cancer stem cells regulate cancer-associated fibroblasts via activation of hedgehog signaling in mammary gland tumors Cancer Res, 77 (8) (2017), pp. 2134-2147

3 L. Li, W. LiEpithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation Pharmacol Ther, 150 (2015), pp. 33-46

4 Y. Kubouchi, Y. Yurugi, M. Wakahara, et al.Podoplanin expression in cancer-associated fibroblasts predicts unfavourable prognosis in patients with pathological stage IA lung adenocarcinoma Histopathology, 72 (3) (2018), pp. 490-499

5 S. Neri, G. Ishii, H. Hashimoto, et al.Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma Int J Cancer, 137 (4) (2015), pp. 784-796

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