Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing

Xue Wang; Han Cheng; Die Hu; Ying Chen; Waseem Hassan; Jing Zhao; Jiuming Li; Zhaohui Huang

doi:10.1016/j.gendis.2023.02.020

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Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing

Short communication | 更新时间：2024-02-04

- Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing
- Genes & Diseases Vol. 1, Issue 6, Pages: 2237-2240(2023)
- 作者机构：
  
  1. Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University,Jiangsu,Wuxi,China,214062
  2. Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University,Jiangsu,Wuxi,China,214062
  3. Wuxi School of Medicine, Jiangnan University,Jiangsu,Wuxi,China,214062
  4. Department of Pharmacy, COMSATS University Islamabad, Lahore Campus,Lahore,Pakistan,54000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.020
  CLC：
- Published：2023，
  
  Published Online：1 November 2023，
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Xue Wang, Han Cheng, Die Hu, et al. Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing. [J]. Genes & Diseases 1(6):2237-2240(2023)
DOI：

Xue Wang, Han Cheng, Die Hu, et al. Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing. [J]. Genes & Diseases 1(6):2237-2240(2023) DOI： 10.1016/j.gendis.2023.02.020.

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1 S. Romano, N. Fonseca, S. Simões, et al.Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands Drug Discov Today, 24 (10) (2019), pp. 1985-2001

2 Y. Kuranaga, N. Sugito, H. Shinohara, et al.SRSF3, a splicer of the PKM gene, regulates cell growth and maintenance of cancer-specific energy metabolism in colon cancer cells Int J Mol Sci, 19 (10) (2018), p. 3012

3 Z. Bian, J. Zhang, M. Li, et al.LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling Clin Cancer Res, 24 (19) (2018), pp. 4808-4819

4 J. Zhao, J. Li, W. Hassan, et al.Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing Ann Transl Med, 8 (7) (2020), p. 459

5 H. Tang, Y. Pan, Y. Zhang, et al.Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment J Control Release, 349 (2022), pp. 592-605

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